Sparse evidence of MERS-CoV infection among animal workers living in Southern Saudi Arabia during 2012

Middle East respiratory syndrome coronavirus (MERS-CoV) is an emerging viral pathogen that primarily causes respiratory illness. We conducted a seroprevalence study of banked human serum samples collected in 2012 from Southern Saudi Arabia. Sera from 300 animal workers (17% with daily camel exposure...

Descripción completa

Detalles Bibliográficos
Autores principales: Memish, Ziad A, Alsahly, Ahmad, Masri, Malak al, Heil, Gary L, Anderson, Benjamin D, Peiris, Malik, Khan, Salah Uddin, Gray, Gregory C
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BlackWell Publishing Ltd 2015
Materias:
Short Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4353318/
https://www.ncbi.nlm.nih.gov/pubmed/25470665
http://dx.doi.org/10.1111/irv.12287
_version_ 1782360594498715648
author Memish, Ziad A
Alsahly, Ahmad
Masri, Malak al
Heil, Gary L
Anderson, Benjamin D
Peiris, Malik
Khan, Salah Uddin
Gray, Gregory C
author_facet Memish, Ziad A
Alsahly, Ahmad
Masri, Malak al
Heil, Gary L
Anderson, Benjamin D
Peiris, Malik
Khan, Salah Uddin
Gray, Gregory C
author_sort Memish, Ziad A
collection PubMed
description Middle East respiratory syndrome coronavirus (MERS-CoV) is an emerging viral pathogen that primarily causes respiratory illness. We conducted a seroprevalence study of banked human serum samples collected in 2012 from Southern Saudi Arabia. Sera from 300 animal workers (17% with daily camel exposure) and 50 non-animal-exposed controls were examined for serological evidence of MERS-CoV infection by a pseudoparticle MERS-CoV spike protein neutralization assay. None of the sera reproducibly neutralized the MERS-CoV-pseudotyped lentiviral vector. These data suggest that serological evidence of zoonotic transmission of MERS-CoV was not common among animal workers in Southern Saudi Arabia during July 2012.
format Online
Article
Text
id pubmed-4353318
institution National Center for Biotechnology Information
language English
publishDate 2015
publisher BlackWell Publishing Ltd
record_format MEDLINE/PubMed
spelling pubmed-43533182015-03-20 Sparse evidence of MERS-CoV infection among animal workers living in Southern Saudi Arabia during 2012 Memish, Ziad A Alsahly, Ahmad Masri, Malak al Heil, Gary L Anderson, Benjamin D Peiris, Malik Khan, Salah Uddin Gray, Gregory C Influenza Other Respir Viruses Short Articles Middle East respiratory syndrome coronavirus (MERS-CoV) is an emerging viral pathogen that primarily causes respiratory illness. We conducted a seroprevalence study of banked human serum samples collected in 2012 from Southern Saudi Arabia. Sera from 300 animal workers (17% with daily camel exposure) and 50 non-animal-exposed controls were examined for serological evidence of MERS-CoV infection by a pseudoparticle MERS-CoV spike protein neutralization assay. None of the sera reproducibly neutralized the MERS-CoV-pseudotyped lentiviral vector. These data suggest that serological evidence of zoonotic transmission of MERS-CoV was not common among animal workers in Southern Saudi Arabia during July 2012. BlackWell Publishing Ltd 2015-03 2014-12-03 /pmc/articles/PMC4353318/ /pubmed/25470665 http://dx.doi.org/10.1111/irv.12287 Text en © 2014 The Authors. Influenza and Other Respiratory Viruses Published by John Wiley & Sons Ltd. http://creativecommons.org/licenses/by/3.0/ This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Short Articles
Memish, Ziad A
Alsahly, Ahmad
Masri, Malak al
Heil, Gary L
Anderson, Benjamin D
Peiris, Malik
Khan, Salah Uddin
Gray, Gregory C
Sparse evidence of MERS-CoV infection among animal workers living in Southern Saudi Arabia during 2012
title Sparse evidence of MERS-CoV infection among animal workers living in Southern Saudi Arabia during 2012
title_full Sparse evidence of MERS-CoV infection among animal workers living in Southern Saudi Arabia during 2012
title_fullStr Sparse evidence of MERS-CoV infection among animal workers living in Southern Saudi Arabia during 2012
title_full_unstemmed Sparse evidence of MERS-CoV infection among animal workers living in Southern Saudi Arabia during 2012
title_short Sparse evidence of MERS-CoV infection among animal workers living in Southern Saudi Arabia during 2012
title_sort sparse evidence of mers-cov infection among animal workers living in southern saudi arabia during 2012
topic Short Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4353318/
https://www.ncbi.nlm.nih.gov/pubmed/25470665
http://dx.doi.org/10.1111/irv.12287
work_keys_str_mv AT memishziada sparseevidenceofmerscovinfectionamonganimalworkerslivinginsouthernsaudiarabiaduring2012
AT alsahlyahmad sparseevidenceofmerscovinfectionamonganimalworkerslivinginsouthernsaudiarabiaduring2012
AT masrimalakal sparseevidenceofmerscovinfectionamonganimalworkerslivinginsouthernsaudiarabiaduring2012
AT heilgaryl sparseevidenceofmerscovinfectionamonganimalworkerslivinginsouthernsaudiarabiaduring2012
AT andersonbenjamind sparseevidenceofmerscovinfectionamonganimalworkerslivinginsouthernsaudiarabiaduring2012
AT peirismalik sparseevidenceofmerscovinfectionamonganimalworkerslivinginsouthernsaudiarabiaduring2012
AT khansalahuddin sparseevidenceofmerscovinfectionamonganimalworkerslivinginsouthernsaudiarabiaduring2012
AT graygregoryc sparseevidenceofmerscovinfectionamonganimalworkerslivinginsouthernsaudiarabiaduring2012

Ejemplares similares