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Large-scale Clinical-grade Retroviral Vector Production in a Fixed-Bed Bioreactor

The successful genetic engineering of patient T cells with γ-retroviral vectors expressing chimeric antigen receptors or T-cell receptors for phase II clinical trials and beyond requires the large-scale manufacture of high-titer vector stocks. The production of retroviral vectors from stable packagi...

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Detalles Bibliográficos
Autores principales:	Wang, Xiuyan, Olszewska, Malgorzata, Qu, Jinrong, Wasielewska, Teresa, Bartido, Shirley, Hermetet, Gregory, Sadelain, Michel, Rivière, Isabelle
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Lippincott Williams & Wilkins 2015
Materias:	Clinical Study
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4353472/ https://www.ncbi.nlm.nih.gov/pubmed/25751502 http://dx.doi.org/10.1097/CJI.0000000000000072

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