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Investigating Different Duplication Pattern of Essential Genes in Mouse and Human
Gene duplication is one of the major driving forces shaping genome and organism evolution and thought to be itself regulated by some intrinsic properties of the gene. Comparing the essential genes among mouse and human, we observed that the essential genes avoid duplication in mouse while prefer to...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4353620/ https://www.ncbi.nlm.nih.gov/pubmed/25751152 http://dx.doi.org/10.1371/journal.pone.0120784 |
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author | Acharya, Debarun Mukherjee, Dola Podder, Soumita Ghosh, Tapash C. |
author_facet | Acharya, Debarun Mukherjee, Dola Podder, Soumita Ghosh, Tapash C. |
author_sort | Acharya, Debarun |
collection | PubMed |
description | Gene duplication is one of the major driving forces shaping genome and organism evolution and thought to be itself regulated by some intrinsic properties of the gene. Comparing the essential genes among mouse and human, we observed that the essential genes avoid duplication in mouse while prefer to remain duplicated in humans. In this study, we wanted to explore the reasons behind such differences in gene essentiality by cross-species comparison of human and mouse. Moreover, we examined essential genes that are duplicated in humans are functionally more redundant than that in mouse. The proportion of paralog pseudogenization of essential genes is higher in mouse than that of humans. These duplicates of essential genes are under stringent dosage regulation in human than in mouse. We also observed slower evolutionary rate in the paralogs of human essential genes than the mouse counterpart. Together, these results clearly indicate that human essential genes are retained as duplicates to serve as backed up copies that may shield themselves from harmful mutations. |
format | Online Article Text |
id | pubmed-4353620 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-43536202015-03-17 Investigating Different Duplication Pattern of Essential Genes in Mouse and Human Acharya, Debarun Mukherjee, Dola Podder, Soumita Ghosh, Tapash C. PLoS One Research Article Gene duplication is one of the major driving forces shaping genome and organism evolution and thought to be itself regulated by some intrinsic properties of the gene. Comparing the essential genes among mouse and human, we observed that the essential genes avoid duplication in mouse while prefer to remain duplicated in humans. In this study, we wanted to explore the reasons behind such differences in gene essentiality by cross-species comparison of human and mouse. Moreover, we examined essential genes that are duplicated in humans are functionally more redundant than that in mouse. The proportion of paralog pseudogenization of essential genes is higher in mouse than that of humans. These duplicates of essential genes are under stringent dosage regulation in human than in mouse. We also observed slower evolutionary rate in the paralogs of human essential genes than the mouse counterpart. Together, these results clearly indicate that human essential genes are retained as duplicates to serve as backed up copies that may shield themselves from harmful mutations. Public Library of Science 2015-03-09 /pmc/articles/PMC4353620/ /pubmed/25751152 http://dx.doi.org/10.1371/journal.pone.0120784 Text en © 2015 Acharya et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited. |
spellingShingle | Research Article Acharya, Debarun Mukherjee, Dola Podder, Soumita Ghosh, Tapash C. Investigating Different Duplication Pattern of Essential Genes in Mouse and Human |
title | Investigating Different Duplication Pattern of Essential Genes in Mouse and Human |
title_full | Investigating Different Duplication Pattern of Essential Genes in Mouse and Human |
title_fullStr | Investigating Different Duplication Pattern of Essential Genes in Mouse and Human |
title_full_unstemmed | Investigating Different Duplication Pattern of Essential Genes in Mouse and Human |
title_short | Investigating Different Duplication Pattern of Essential Genes in Mouse and Human |
title_sort | investigating different duplication pattern of essential genes in mouse and human |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4353620/ https://www.ncbi.nlm.nih.gov/pubmed/25751152 http://dx.doi.org/10.1371/journal.pone.0120784 |
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