Structural Insights into Ca(2+)-Calmodulin Regulation of Plectin 1a-Integrin β4 Interaction in Hemidesmosomes

The mechanical stability of epithelial cells, which protect organisms from harmful external factors, is maintained by hemidesmosomes via the interaction between plectin 1a (P1a) and integrin α6β4. Binding of calcium-calmodulin (Ca(2+)-CaM) to P1a together with phosphorylation of integrin β4 disrupts...

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Detalles Bibliográficos
Autores principales: Song, Jae-Geun, Kostan, Julius, Drepper, Friedel, Knapp, Bettina, de Almeida Ribeiro, Euripedes, Konarev, Petr V., Grishkovskaya, Irina, Wiche, Gerhard, Gregor, Martin, Svergun, Dmitri I., Warscheid, Bettina, Djinović-Carugo, Kristina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4353693/
https://www.ncbi.nlm.nih.gov/pubmed/25703379
http://dx.doi.org/10.1016/j.str.2015.01.011

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4353693/
https://www.ncbi.nlm.nih.gov/pubmed/25703379
http://dx.doi.org/10.1016/j.str.2015.01.011

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