Cargando…

Structural Insights into Ca(2+)-Calmodulin Regulation of Plectin 1a-Integrin β4 Interaction in Hemidesmosomes

The mechanical stability of epithelial cells, which protect organisms from harmful external factors, is maintained by hemidesmosomes via the interaction between plectin 1a (P1a) and integrin α6β4. Binding of calcium-calmodulin (Ca(2+)-CaM) to P1a together with phosphorylation of integrin β4 disrupts...

Descripción completa

Detalles Bibliográficos
Autores principales:	Song, Jae-Geun, Kostan, Julius, Drepper, Friedel, Knapp, Bettina, de Almeida Ribeiro, Euripedes, Konarev, Petr V., Grishkovskaya, Irina, Wiche, Gerhard, Gregor, Martin, Svergun, Dmitri I., Warscheid, Bettina, Djinović-Carugo, Kristina
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Cell Press 2015
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4353693/ https://www.ncbi.nlm.nih.gov/pubmed/25703379 http://dx.doi.org/10.1016/j.str.2015.01.011

Ejemplares similares

β4 integrin is not essential for localization of hemidesmosome proteins plectin and CD151 in cerebral vessels
por: Welser-Alves, Jennifer V, et al.
Publicado: (2016)

Targeted Proteolysis of Plectin Isoform 1a Accounts for Hemidesmosome Dysfunction in Mice Mimicking the Dominant Skin Blistering Disease EBS-Ogna
por: Walko, Gernot, et al.
Publicado: (2011)

Molecular basis of F-actin regulation and sarcomere assembly via myotilin
por: Kostan, Julius, et al.
Publicado: (2021)

Plectin in Health and Disease
por: Wiche, Gerhard
Publicado: (2022)

Role of calcium and calmodulin in hemidesmosome formation in vitro
Publicado: (1984)

Molecular architecture and function of the hemidesmosome
por: Walko, Gernot, et al.
Publicado: (2015)

Molecular architecture and function of the hemidesmosome
por: Walko, Gernot, et al.
Publicado: (2014)

Order from disorder in the sarcomere: FATZ forms a fuzzy but tight complex and phase-separated condensates with α-actinin
por: Sponga, Antonio, et al.
Publicado: (2021)

Deciphering the BAR code of membrane modulators
por: Salzer, Ulrich, et al.
Publicado: (2017)

Reprogramming of the transcriptome after heat stress mediates heat hormesis in Caenorhabditis elegans
por: Xu, Fan, et al.
Publicado: (2023)

Plectin-Mediated Intermediate Filament Functions: Why Isoforms Matter
por: Wiche, Gerhard
Publicado: (2021)

Identifying Plectin Isoform Functions through Animal Models
por: Castañón, Maria J., et al.
Publicado: (2021)

Structural flexibility of RNA as molecular basis for Hfq chaperone function
por: de Almeida Ribeiro, Euripedes, et al.
Publicado: (2012)

Molecular mechanism of leukocidin GH–integrin CD11b/CD18 recognition and species specificity
por: Trstenjak, Nikolina, et al.
Publicado: (2020)

The Structure and Regulation of Human Muscle α-Actinin
por: Ribeiro, Euripedes de Almeida, et al.
Publicado: (2014)

Disassembly of α6β4-mediated hemidesmosomal adhesions promotes tumorigenesis in PTEN-negative prostate cancer by targeting plectin to focal adhesions
por: Wenta, Tomasz, et al.
Publicado: (2022)

Plectin–intermediate filament partnership in skin, skeletal muscle, and peripheral nerve
por: Castañón, Maria J., et al.
Publicado: (2013)

Plectin-controlled keratin cytoarchitecture affects MAP kinases involved in cellular stress response and migration
por: Osmanagic-Myers, Selma, et al.
Publicado: (2006)

Hemidesmosome Formation Is Initiated by the β4 Integrin Subunit, Requires Complex Formation of β4 and HD1/Plectin, and Involves a Direct Interaction between β4 and the Bullous Pemphigoid Antigen 180
por: Schaapveld, Roel Q.J., et al.
Publicado: (1998)

Structure and calcium-binding studies of calmodulin-like domain of human non-muscle α-actinin-1
por: Drmota Prebil, Sara, et al.
Publicado: (2016)

Structures of three MORN repeat proteins and a re-evaluation of the proposed lipid-binding properties of MORN repeats
por: Sajko, Sara, et al.
Publicado: (2020)

Determining the mechanical properties of plectin in mouse myoblasts and keratinocytes
por: Bonakdar, Navid, et al.
Publicado: (2015)

Keeping the Vimentin Network under Control: Cell–Matrix Adhesion–associated Plectin 1f Affects Cell Shape and Polarity of Fibroblasts
por: Burgstaller, Gerald, et al.
Publicado: (2010)

A combinatorial native MS and LC-MS/MS approach reveals high intrinsic phosphorylation of human Tau but minimal levels of other key modifications
por: Drepper, Friedel, et al.
Publicado: (2021)

Beta4 integrin is required for hemidesmosome formation, cell adhesion and cell survival
Publicado: (1996)

The Tetraspan Molecule Cd151, a Novel Constituent of Hemidesmosomes, Associates with the Integrin α6β4 and May Regulate the Spatial Organization of Hemidesmosomes
por: Sterk, Lotus M.Th., et al.
Publicado: (2000)

Plectin-mediated cytoskeletal crosstalk controls cell tension and cohesion in epithelial sheets
por: Prechova, Magdalena, et al.
Publicado: (2022)

Linking Integrin α(6)β(4)-based Cell Adhesion to the Intermediate Filament Cytoskeleton: Direct Interaction between the β(4) Subunit and Plectin at Multiple Molecular Sites
por: Rezniczek, Günther A., et al.
Publicado: (1998)

Binding of Integrin α6β4 to Plectin Prevents Plectin Association with F-Actin but Does Not Interfere with Intermediate Filament Binding
por: Geerts, Dirk, et al.
Publicado: (1999)

Plectin isoform 1b mediates mitochondrion–intermediate filament network linkage and controls organelle shape
por: Winter, Lilli, et al.
Publicado: (2008)

Plectin isoform 1-dependent nuclear docking of desmin networks affects myonuclear architecture and expression of mechanotransducers
por: Staszewska, Ilona, et al.
Publicado: (2015)

Hemidesmosome formation in vitro
Publicado: (1983)

The Pseudomonas aeruginosa Catabolite Repression Control Protein Crc Is Devoid of RNA Binding Activity
por: Milojevic, Tetyana, et al.
Publicado: (2013)

The Hsp70 homolog Ssb and the 14-3-3 protein Bmh1 jointly regulate transcription of glucose repressed genes in Saccharomyces cerevisiae
por: Hübscher, Volker, et al.
Publicado: (2016)

The interaction network of the YidC insertase with the SecYEG translocon, SRP and the SRP receptor FtsY
por: Petriman, Narcis-Adrian, et al.
Publicado: (2018)

Plectin linkages are mechanosensitive and required for the nuclear piston mechanism of three-dimensional cell migration
por: Marks, Pragati C., et al.
Publicado: (2022)

Intermediate filament-associated cytolinker plectin 1c destabilizes microtubules in keratinocytes
por: Valencia, Rocio G., et al.
Publicado: (2013)

Phosphoproteomics identifies dual-site phosphorylation in an extended basophilic motif regulating FILIP1-mediated degradation of filamin-C
por: Reimann, Lena, et al.
Publicado: (2020)

Promiscuous targeting of polytopic membrane proteins to SecYEG or YidC by the Escherichia coli signal recognition particle
por: Welte, Thomas, et al.
Publicado: (2012)

Phosphorylation of threonine 1736 in the C-terminal tail of integrin β4 contributes to hemidesmosome disassembly
por: Frijns, Evelyne, et al.
Publicado: (2012)

Cannot write session to /tmp/vufind_sessions/sess_sacl3emlj2eo4c23ffcfbunvo5