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Serum levels of specific IgE to Staphylococcus aureus enterotoxins in patients with chronic rhinosinusitis

The aim of this study was to determine the prevalence of Staphylococcus aureus enterotoxins (SEs) in the serum from patients with chronic rhinosinusitis (CRS) and its involvement in the condition. Thirty CRS patients without nasal polyps (CRSsNP), 40 CRS patients with nasal polyps (CRSwNP), and 30 h...

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Autores principales: CUI, XIN-YAN, MIAO, JIAN-LIANG, LU, HAN-QIANG, QI, QIN-HONG, CHEN, XI, XU, JIN, LIN, ZI-PING, CHEN, ZHI-BIN, YIN, MIN, CHENG, LEI
Formato: Online Artículo Texto
Lenguaje:English
Publicado: D.A. Spandidos 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4353786/
https://www.ncbi.nlm.nih.gov/pubmed/25780463
http://dx.doi.org/10.3892/etm.2015.2247
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author CUI, XIN-YAN
MIAO, JIAN-LIANG
LU, HAN-QIANG
QI, QIN-HONG
CHEN, XI
XU, JIN
LIN, ZI-PING
CHEN, ZHI-BIN
YIN, MIN
CHENG, LEI
author_facet CUI, XIN-YAN
MIAO, JIAN-LIANG
LU, HAN-QIANG
QI, QIN-HONG
CHEN, XI
XU, JIN
LIN, ZI-PING
CHEN, ZHI-BIN
YIN, MIN
CHENG, LEI
author_sort CUI, XIN-YAN
collection PubMed
description The aim of this study was to determine the prevalence of Staphylococcus aureus enterotoxins (SEs) in the serum from patients with chronic rhinosinusitis (CRS) and its involvement in the condition. Thirty CRS patients without nasal polyps (CRSsNP), 40 CRS patients with nasal polyps (CRSwNP), and 30 healthy controls were enrolled in this study. Peripheral blood was obtained and analyzed to measure the serum levels of total IgE, specific IgE to SEA, SEB and SEC, and eosinophil cationic protein (ECP) using ImmunoCAP assays. The positive rate and level of serum specific IgE to SEB, but not to SEA or SEC, were significantly higher in CRSwNP patients compared with the controls (P=0.027 and P=0.021, respectively). No significant differences were found between CRSsNP patients and controls, or between CRSsNP and CRSwNP patients. Serum total IgE was significantly elevated and positively correlated with SEB-specific IgE in the CRSsNP (P<0.001; r=0.393, P=0.032) and CRSwNP (P<0.001; r=0.581, P<0.001) groups. ECP was also significantly increased in the CRSsNP (P=0.002) and CRSwNP (P<0.001) groups, but not correlated with specific IgE to SEs in either CRS group. The results suggest that SEB may play a role in the pathogenesis of CRSwNP.
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spelling pubmed-43537862015-03-16 Serum levels of specific IgE to Staphylococcus aureus enterotoxins in patients with chronic rhinosinusitis CUI, XIN-YAN MIAO, JIAN-LIANG LU, HAN-QIANG QI, QIN-HONG CHEN, XI XU, JIN LIN, ZI-PING CHEN, ZHI-BIN YIN, MIN CHENG, LEI Exp Ther Med Articles The aim of this study was to determine the prevalence of Staphylococcus aureus enterotoxins (SEs) in the serum from patients with chronic rhinosinusitis (CRS) and its involvement in the condition. Thirty CRS patients without nasal polyps (CRSsNP), 40 CRS patients with nasal polyps (CRSwNP), and 30 healthy controls were enrolled in this study. Peripheral blood was obtained and analyzed to measure the serum levels of total IgE, specific IgE to SEA, SEB and SEC, and eosinophil cationic protein (ECP) using ImmunoCAP assays. The positive rate and level of serum specific IgE to SEB, but not to SEA or SEC, were significantly higher in CRSwNP patients compared with the controls (P=0.027 and P=0.021, respectively). No significant differences were found between CRSsNP patients and controls, or between CRSsNP and CRSwNP patients. Serum total IgE was significantly elevated and positively correlated with SEB-specific IgE in the CRSsNP (P<0.001; r=0.393, P=0.032) and CRSwNP (P<0.001; r=0.581, P<0.001) groups. ECP was also significantly increased in the CRSsNP (P=0.002) and CRSwNP (P<0.001) groups, but not correlated with specific IgE to SEs in either CRS group. The results suggest that SEB may play a role in the pathogenesis of CRSwNP. D.A. Spandidos 2015-04 2015-02-02 /pmc/articles/PMC4353786/ /pubmed/25780463 http://dx.doi.org/10.3892/etm.2015.2247 Text en Copyright © 2015, Spandidos Publications http://creativecommons.org/licenses/by/3.0 This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited.
spellingShingle Articles
CUI, XIN-YAN
MIAO, JIAN-LIANG
LU, HAN-QIANG
QI, QIN-HONG
CHEN, XI
XU, JIN
LIN, ZI-PING
CHEN, ZHI-BIN
YIN, MIN
CHENG, LEI
Serum levels of specific IgE to Staphylococcus aureus enterotoxins in patients with chronic rhinosinusitis
title Serum levels of specific IgE to Staphylococcus aureus enterotoxins in patients with chronic rhinosinusitis
title_full Serum levels of specific IgE to Staphylococcus aureus enterotoxins in patients with chronic rhinosinusitis
title_fullStr Serum levels of specific IgE to Staphylococcus aureus enterotoxins in patients with chronic rhinosinusitis
title_full_unstemmed Serum levels of specific IgE to Staphylococcus aureus enterotoxins in patients with chronic rhinosinusitis
title_short Serum levels of specific IgE to Staphylococcus aureus enterotoxins in patients with chronic rhinosinusitis
title_sort serum levels of specific ige to staphylococcus aureus enterotoxins in patients with chronic rhinosinusitis
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4353786/
https://www.ncbi.nlm.nih.gov/pubmed/25780463
http://dx.doi.org/10.3892/etm.2015.2247
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