Cargando…

Cbl-b-regulated extracellular signal-regulated kinase signaling is involved in the shikonin-induced apoptosis of lung cancer cells in vitro

Shikonin (SK), a naturally occurring naphthoquinone, exhibits antitumor activity. However, its precise mechanisms of action are unknown. In the present study, the effects of SK on NCI-H460 human lung cancer cells were investigated. It was found that SK reduced cell viability and induced apoptosis in...

Descripción completa

Detalles Bibliográficos
Autores principales:	QU, DAN, CHEN, YU, XU, XIAO-MAN, ZHANG, MENG, ZHANG, YI, LI, SHENG-QI
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	D.A. Spandidos 2015
Materias:	Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4353798/ https://www.ncbi.nlm.nih.gov/pubmed/25780420 http://dx.doi.org/10.3892/etm.2015.2283

Ejemplares similares

Abnormal regulation of BCR signalling by c-Cbl in chronic lymphocytic leukaemia
por: Martini, Veronica, et al.
Publicado: (2018)

Shikonin induced Apoptosis Mediated by Endoplasmic Reticulum Stress in Colorectal Cancer Cells
por: Qi, Hui, et al.
Publicado: (2022)

Shikonin Inhibits Cholangiocarcinoma Cell Line QBC939 by Regulating Apoptosis, Proliferation, and Invasion
por: Liu, Chang, et al.
Publicado: (2021)

Phosphatidylethanolamine-binding protein is not involved in μ-opioid receptor-mediated regulation of extracellular signal-regulated kinase
por: BIAN, JIA-MING, et al.
Publicado: (2015)

Shikonin and 4-hydroxytamoxifen synergistically inhibit the proliferation of breast cancer cells through activating apoptosis signaling pathway in vitro and in vivo
por: Lin, Hong-Yan, et al.
Publicado: (2020)

Histone deacetylase 1 and 2 differentially regulate apoptosis by opposing effects on extracellular signal-regulated kinase 1/2
por: Lei, W-W, et al.
Publicado: (2010)

Evidence for the involvement of G(i2) in activation of extracellular signal-regulated kinases in hepatocytes
por: Melien, Øyvind, et al.
Publicado: (2001)

Extracellular signal-regulated kinase, substance P and neurokinin-1 are involved in the analgesic mechanism of herb-partitioned moxibustion
por: Li, Zhi-yuan, et al.
Publicado: (2017)

Src-family kinase-Cbl axis negatively regulates NLRP3 inflammasome activation
por: Chung, I-Che, et al.
Publicado: (2018)

The Brassica napus Calcineurin B-Like 1/CBL-interacting protein kinase 6 (CBL1/CIPK6) component is involved in the plant response to abiotic stress and ABA signalling
por: Chen, Liang, et al.
Publicado: (2012)

Activation of the apoptosis signal-regulating kinase 1/c-Jun N-terminal kinase pathway is involved in the casticin-induced apoptosis of colon cancer cells
por: QU, LIN, et al.
Publicado: (2014)

Annonacin Exerts Antitumor Activity through Induction of Apoptosis and Extracellular Signal-regulated Kinase Inhibition
por: Yap, Chee Voon, et al.
Publicado: (2017)

Regulation of neuronal survival by the extracellular signal-regulated protein kinase 5
por: Finegan, Katherine G., et al.
Publicado: (2009)

Extracellular signal-regulated kinases 1/2 as regulators of cardiac hypertrophy
por: Mutlak, Michael, et al.
Publicado: (2015)

Blockage of Extracellular Signal-Regulated Kinase Exerts an Antitumor Effect via Regulating Energy Metabolism and Enhances the Efficacy of Autophagy Inhibitors by Regulating Transcription Factor EB Nuclear Translocation in Osteosarcoma
por: Zhang, Man, et al.
Publicado: (2021)

Shikonin induces colorectal carcinoma cells apoptosis and autophagy by targeting galectin-1/JNK signaling axis
por: Zhang, Nan, et al.
Publicado: (2020)

Extracellular signal-regulated kinases associate with and phosphorylate DHPS to promote cell proliferation
por: Wang, Chao, et al.
Publicado: (2020)

Cbl-b Negatively Regulates B Cell Antigen Receptor Signaling in Mature B Cells through Ubiquitination of the Tyrosine Kinase Syk
por: Sohn, Hae Won, et al.
Publicado: (2003)

Prostaglandin F2α Regulates Adipogenesis by Modulating Extracellular Signal-Regulated Kinase Signaling in Graves’ Ophthalmopathy
por: Zhu, Ru, et al.
Publicado: (2023)

The calcium sensor OsCBL1 modulates nitrate signaling to regulate seedling growth in rice
por: Yang, Jing, et al.
Publicado: (2019)

Apoptosis signal-regulating kinase 1 inhibition in in vivo and in vitro models of pulmonary hypertension
por: Wilson, Kathryn S., et al.
Publicado: (2020)

Prevention of tumour cell apoptosis associated with sustained protein kinase B phosphorylation is more sensitive to regulation by insulin signalling than stimulation of proliferation and extracellular signal-regulated kinase
por: Schmid, Christoph, et al.
Publicado: (2017)

Rab23 contributes to the progression of colorectal cancer via protein kinase B and extracellular signal-regulated kinase signaling pathways
por: Zhao, Tongbi, et al.
Publicado: (2019)

β-hydroxyisovaleryl-shikonin induces human cervical cancer cell apoptosis via PI3K/AKT/mTOR signaling
por: LU, DAN, et al.
Publicado: (2015)

β-Hydroxyisovaleryl-shikonin induces human cervical cancer cell apoptosis via PI3K/AKT/mTOR signaling
por: Lu, Dan, et al.
Publicado: (2021)

Oncostatin M receptor regulates osteoblast differentiation via extracellular signal-regulated kinase/autophagy signaling
por: Zhou, Jie, et al.
Publicado: (2022)

Extracellular Signal‐Regulated Kinase 5 Regulates the Malignant Phenotype of Cholangiocarcinoma Cells
por: Gentilini, Alessandra, et al.
Publicado: (2021)

Pre-LTP requires extracellular signal-regulated kinase in the ACC
por: Yamanaka, Manabu, et al.
Publicado: (2016)

Extracellular signal regulated kinase 5 and inflammasome in progression of mesothelioma
por: Thompson, Joyce K., et al.
Publicado: (2017)

Rosiglitazone attenuates the metalloprotease/anti-metalloprotease imbalance in emphysema induced by cigarette smoke: involvement of extracellular signal-regulated kinase and NFκB signaling
por: Hou, Gang, et al.
Publicado: (2015)

The Extracellular Signal-Regulated Kinase Mitogen-Activated Protein Kinase Pathway in Osteoblasts
por: Greenblatt, Matthew B., et al.
Publicado: (2022)

Androgen-dependent apoptosis in male germ cells is regulated through the proto-oncoprotein Cbl
por: El Chami, Nisrine, et al.
Publicado: (2005)

Haem oxygenase-1 induction prevents glucocorticoid-induced osteoblast apoptosis through activation of extracellular signal–regulated kinase1/2 signalling pathway
por: Gu, Qiaoli, et al.
Publicado: (2019)

Extracellular Signal-Regulated Kinase Signaling in CD4-Expressing Cells Inhibits Osteochondromas
por: Wehenkel, Marie, et al.
Publicado: (2017)

Role of extracellular signal-regulated kinase 1/2 signaling underlying cardiac hypertrophy
por: Yan, Zhi-Peng, et al.
Publicado: (2021)

CBL-Interacting Protein Kinases 18 (CIPK18) Gene Positively Regulates Drought Resistance in Potato
por: Yang, Liang, et al.
Publicado: (2023)

Regulation of EGFR Endocytosis by CBL During Mitosis
por: Wee, Ping, et al.
Publicado: (2018)

The CBL–CIPK Pathway in Plant Response to Stress Signals
por: Ma, Xiao, et al.
Publicado: (2020)

Presynaptic long-term potentiation requires extracellular signal-regulated kinases in the anterior cingulate cortex
por: Chen, Qi-Yu, et al.
Publicado: (2020)

Extracellular signals regulate the biogenesis of extracellular vesicles
por: Jin, Yong, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_hqetmg6luf7cqdh73a5dhu04d6