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Canadian Public Health Laboratory Network laboratory guidelines for the use of point-of-care tests for the diagnosis of syphilis in Canada
Syphilis point-of-care tests (POCT) are widely available in developing countries enabling early diagnosis, treatment and support. The majority of commercially available tests use treponemal antigens and the presence of antibodies does not distinguish between current and past infection, which may lea...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Pulsus Group Inc
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4353982/ https://www.ncbi.nlm.nih.gov/pubmed/25798163 |
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author | Singh, Ameeta E Chernesky, Max A Morshed, Muhammad Wong, Tom |
author_facet | Singh, Ameeta E Chernesky, Max A Morshed, Muhammad Wong, Tom |
author_sort | Singh, Ameeta E |
collection | PubMed |
description | Syphilis point-of-care tests (POCT) are widely available in developing countries enabling early diagnosis, treatment and support. The majority of commercially available tests use treponemal antigens and the presence of antibodies does not distinguish between current and past infection, which may lead to unnecessary antibiotic use and stigmatization of having a current STI. In hard-to-reach populations, the benefits may outweigh the risks. Available studies show reasonable performance of POCT with median sensitivity of 86%, specificity of 99% and positive predictive values >80% when prevalence was >0.3%. Although no syphilis POCT are approved in Canada at this time, a single study in an outreach setting in Alberta showed limited benefit due to a high prevalence of previous infection but more studies are needed. Newer dual tests employing treponemal and nontreponemal antigens look promising. |
format | Online Article Text |
id | pubmed-4353982 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Pulsus Group Inc |
record_format | MEDLINE/PubMed |
spelling | pubmed-43539822015-03-20 Canadian Public Health Laboratory Network laboratory guidelines for the use of point-of-care tests for the diagnosis of syphilis in Canada Singh, Ameeta E Chernesky, Max A Morshed, Muhammad Wong, Tom Can J Infect Dis Med Microbiol CPHLN Laboratory Guidelines Syphilis point-of-care tests (POCT) are widely available in developing countries enabling early diagnosis, treatment and support. The majority of commercially available tests use treponemal antigens and the presence of antibodies does not distinguish between current and past infection, which may lead to unnecessary antibiotic use and stigmatization of having a current STI. In hard-to-reach populations, the benefits may outweigh the risks. Available studies show reasonable performance of POCT with median sensitivity of 86%, specificity of 99% and positive predictive values >80% when prevalence was >0.3%. Although no syphilis POCT are approved in Canada at this time, a single study in an outreach setting in Alberta showed limited benefit due to a high prevalence of previous infection but more studies are needed. Newer dual tests employing treponemal and nontreponemal antigens look promising. Pulsus Group Inc 2015 /pmc/articles/PMC4353982/ /pubmed/25798163 Text en Copyright© 2015 Pulsus Group Inc. All rights reserved This open-access article is distributed under the terms of the Creative Commons Attribution Non-Commercial License (CC BY-NC) (http://creativecommons.org/licenses/by-nc/4.0/), which permits reuse, distribution and reproduction of the article, provided that the original work is properly cited and the reuse is restricted to noncommercial purposes. For commercial reuse, contact support@pulsus.com |
spellingShingle | CPHLN Laboratory Guidelines Singh, Ameeta E Chernesky, Max A Morshed, Muhammad Wong, Tom Canadian Public Health Laboratory Network laboratory guidelines for the use of point-of-care tests for the diagnosis of syphilis in Canada |
title | Canadian Public Health Laboratory Network laboratory guidelines for the use of point-of-care tests for the diagnosis of syphilis in Canada |
title_full | Canadian Public Health Laboratory Network laboratory guidelines for the use of point-of-care tests for the diagnosis of syphilis in Canada |
title_fullStr | Canadian Public Health Laboratory Network laboratory guidelines for the use of point-of-care tests for the diagnosis of syphilis in Canada |
title_full_unstemmed | Canadian Public Health Laboratory Network laboratory guidelines for the use of point-of-care tests for the diagnosis of syphilis in Canada |
title_short | Canadian Public Health Laboratory Network laboratory guidelines for the use of point-of-care tests for the diagnosis of syphilis in Canada |
title_sort | canadian public health laboratory network laboratory guidelines for the use of point-of-care tests for the diagnosis of syphilis in canada |
topic | CPHLN Laboratory Guidelines |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4353982/ https://www.ncbi.nlm.nih.gov/pubmed/25798163 |
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