Proteomic screen reveals Fbw7 as a modulator of the NF-κB pathway

Fbw7 is a ubiquitin-ligase that targets several oncoproteins for proteolysis, but the full range of Fbw7 substrates is not known. Here we show that by performing quantitative proteomics combined with degron motif searches, we effectively screened for a more complete set of Fbw7 targets. We identify...

Descripción completa

Detalles Bibliográficos
Autores principales: Arabi, Azadeh, Ullah, Karim, Branca, Rui M.M., Johansson, Johan, Bandarra, Daniel, Haneklaus, Moritz, Fu, Jing, Ariës, Ingrid, Nilsson, Peter, Den Boer, Monique L., Pokrovskaja, Katja, Grandér, Dan, Xiao, Gutian, Rocha, Sonia, Lehtiö, Janne, Sangfelt, Olle
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Pub. Group 2012
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4354031/
https://www.ncbi.nlm.nih.gov/pubmed/22864569
http://dx.doi.org/10.1038/ncomms1975

Ejemplares similares

Ejemplares similares