Cargando…
DNA sequencing using polymerase substrate-binding kinetics
Next-generation sequencing (NGS) has transformed genomic research by decreasing the cost of sequencing. However, whole-genome sequencing is still costly and complex for diagnostics purposes. In the clinical space, targeted sequencing has the advantage of allowing researchers to focus on specific gen...
Autores principales: | Previte, Michael John Robert, Zhou, Chunhong, Kellinger, Matthew, Pantoja, Rigo, Chen, Cheng-Yao, Shi, Jin, Wang, BeiBei, Kia, Amirali, Etchin, Sergey, Vieceli, John, Nikoomanzar, Ali, Bomati, Erin, Gloeckner, Christian, Ronaghi, Mostafa, He, Molly Min |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Pub. Group
2015
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4354037/ https://www.ncbi.nlm.nih.gov/pubmed/25612848 http://dx.doi.org/10.1038/ncomms6936 |
Ejemplares similares
-
Improved genome sequencing using an engineered transposase
por: Kia, Amirali, et al.
Publicado: (2017) -
5-Formyl- and 5-carboxyl-cytosine reduce the rate and substrate specificity of RNA polymerase II transcription
por: Kellinger, Matthew W., et al.
Publicado: (2012) -
Structural basis for TNA synthesis by an engineered TNA polymerase
por: Chim, Nicholas, et al.
Publicado: (2017) -
Kinetic analysis of N-alkylaryl carboxamide hexitol nucleotides as substrates for evolved polymerases
por: Renders, Marleen, et al.
Publicado: (2019) -
Balancing Non-Equilibrium Driving with Nucleotide Selectivity at Kinetic Checkpoints in Polymerase Fidelity Control
por: Long, Chunhong, et al.
Publicado: (2018)