Human Multidrug Resistance 1 gene polymorphisms and Idiopathic Pulmonary Fibrosis

BACKGROUND: For the first time we tested an association between the human multidrug resistance gene 1 (MDR1) polymorphisms (SNPs) and idiopathic pulmonary fibrosis (IPF). Several MDR1 polymorphisms are associated with pathologies in which they modify the drug susceptibility and pharmacokinetics. MAT...

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Detalles Bibliográficos
Autores principales: Martinelli, Marcella, Scapoli, Luca, Pacilli, Angela Maria Grazia, Carbonara, Paolo, Girardi, Ambra, Mattei, Gabriella, Rodia, Maria Teresa, Solmi, Rossella
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2015
Materias:
Short Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4354072/
https://www.ncbi.nlm.nih.gov/pubmed/25767528
Descripción
Sumario:BACKGROUND: For the first time we tested an association between the human multidrug resistance gene 1 (MDR1) polymorphisms (SNPs) and idiopathic pulmonary fibrosis (IPF). Several MDR1 polymorphisms are associated with pathologies in which they modify the drug susceptibility and pharmacokinetics. MATERIALS AND METHODS: We genotyped three MDR1 polymorphisms of 48 IPF patients and 100 control subjects with Italian origins. RESULTS: No evidence of association was detected. CONCLUSION: There are 50 known MDR1 SNPs, and their role is explored in terms of the effectiveness of drug therapy. We consider our small-scale preliminary study as a starting point for further research.

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