Morphological and migratory alterations in retinal Müller cells during early stages of hypoxia and oxidative stress☆

In the present study, retinal Müller cells were cultured in vitro and treated with hydrogen peroxide (oxidative stressor) and cobalt chloride (hypoxic injury). Following 24 hours of culture, compensatory hypertrophy was observed and cellular apoptosis increased. Hypoxia enhanced the migration abilit...

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Detalles Bibliográficos
Autores principales: Zhang, Xiaohui, Feng, Zhaohui, Li, Chunhua, Zheng, Yuping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2012
Materias:
Research and Report: Neurogensis and Neural Plasticicty
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4354112/
https://www.ncbi.nlm.nih.gov/pubmed/25806055
http://dx.doi.org/10.3969/j.issn.1673-5374.2012.01.005
Descripción
Sumario:In the present study, retinal Müller cells were cultured in vitro and treated with hydrogen peroxide (oxidative stressor) and cobalt chloride (hypoxic injury). Following 24 hours of culture, compensatory hypertrophy was observed and cellular apoptosis increased. Hypoxia enhanced the migration ability of retinal Müller cells and induced the expression of α-smooth muscle actin. Oxidative stress altered the morphology of Müller cells when compared with hypoxia treatment.

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