Morphological and migratory alterations in retinal Müller cells during early stages of hypoxia and oxidative stress☆

In the present study, retinal Müller cells were cultured in vitro and treated with hydrogen peroxide (oxidative stressor) and cobalt chloride (hypoxic injury). Following 24 hours of culture, compensatory hypertrophy was observed and cellular apoptosis increased. Hypoxia enhanced the migration abilit...

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Autores principales: Zhang, Xiaohui, Feng, Zhaohui, Li, Chunhua, Zheng, Yuping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2012
Materias:
Research and Report: Neurogensis and Neural Plasticicty
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4354112/
https://www.ncbi.nlm.nih.gov/pubmed/25806055
http://dx.doi.org/10.3969/j.issn.1673-5374.2012.01.005
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author Zhang, Xiaohui
Feng, Zhaohui
Li, Chunhua
Zheng, Yuping
author_facet Zhang, Xiaohui
Feng, Zhaohui
Li, Chunhua
Zheng, Yuping
author_sort Zhang, Xiaohui
collection PubMed
description In the present study, retinal Müller cells were cultured in vitro and treated with hydrogen peroxide (oxidative stressor) and cobalt chloride (hypoxic injury). Following 24 hours of culture, compensatory hypertrophy was observed and cellular apoptosis increased. Hypoxia enhanced the migration ability of retinal Müller cells and induced the expression of α-smooth muscle actin. Oxidative stress altered the morphology of Müller cells when compared with hypoxia treatment.
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spelling pubmed-43541122015-03-24 Morphological and migratory alterations in retinal Müller cells during early stages of hypoxia and oxidative stress☆ Zhang, Xiaohui Feng, Zhaohui Li, Chunhua Zheng, Yuping Neural Regen Res Research and Report: Neurogensis and Neural Plasticicty In the present study, retinal Müller cells were cultured in vitro and treated with hydrogen peroxide (oxidative stressor) and cobalt chloride (hypoxic injury). Following 24 hours of culture, compensatory hypertrophy was observed and cellular apoptosis increased. Hypoxia enhanced the migration ability of retinal Müller cells and induced the expression of α-smooth muscle actin. Oxidative stress altered the morphology of Müller cells when compared with hypoxia treatment. Medknow Publications & Media Pvt Ltd 2012-01-05 /pmc/articles/PMC4354112/ /pubmed/25806055 http://dx.doi.org/10.3969/j.issn.1673-5374.2012.01.005 Text en Copyright: © Neural Regeneration Research http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research and Report: Neurogensis and Neural Plasticicty
Zhang, Xiaohui
Feng, Zhaohui
Li, Chunhua
Zheng, Yuping
Morphological and migratory alterations in retinal Müller cells during early stages of hypoxia and oxidative stress☆
title Morphological and migratory alterations in retinal Müller cells during early stages of hypoxia and oxidative stress☆
title_full Morphological and migratory alterations in retinal Müller cells during early stages of hypoxia and oxidative stress☆
title_fullStr Morphological and migratory alterations in retinal Müller cells during early stages of hypoxia and oxidative stress☆
title_full_unstemmed Morphological and migratory alterations in retinal Müller cells during early stages of hypoxia and oxidative stress☆
title_short Morphological and migratory alterations in retinal Müller cells during early stages of hypoxia and oxidative stress☆
title_sort morphological and migratory alterations in retinal müller cells during early stages of hypoxia and oxidative stress☆
topic Research and Report: Neurogensis and Neural Plasticicty
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4354112/
https://www.ncbi.nlm.nih.gov/pubmed/25806055
http://dx.doi.org/10.3969/j.issn.1673-5374.2012.01.005
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