Transplantation of autologous bone marrow-derived mesenchymal stem cells for traumatic brain injury☆

Results from the present study demonstrated that transplantation of autologous bone marrow-derived mesenchymal stem cells into the lesion site in rat brain significantly ameliorated brain tissue pathological changes and brain edema, attenuated glial cell proliferation, and increased brain-derived ne...

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Autores principales: Jiang, Jindou, Bu, Xingyao, Liu, Meng, Cheng, Peixun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2012
Materias:
Research and Report: Stem Cells and Neuroregenration
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4354115/
https://www.ncbi.nlm.nih.gov/pubmed/25806058
http://dx.doi.org/10.3969/j.issn.1673-5374.2012.01.008
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author Jiang, Jindou
Bu, Xingyao
Liu, Meng
Cheng, Peixun
author_facet Jiang, Jindou
Bu, Xingyao
Liu, Meng
Cheng, Peixun
author_sort Jiang, Jindou
collection PubMed
description Results from the present study demonstrated that transplantation of autologous bone marrow-derived mesenchymal stem cells into the lesion site in rat brain significantly ameliorated brain tissue pathological changes and brain edema, attenuated glial cell proliferation, and increased brain-derived neurotrophic factor expression. In addition, the number of cells double-labeled for 5-bromodeoxyuridine/glial fibrillary acidic protein and cells expressing nestin increased. Finally, blood vessels were newly generated, and the rats exhibited improved motor and cognitive functions. These results suggested that transplantation of autologous bone marrow-derived mesenchymal stem cells promoted brain remodeling and improved neurological functions following traumatic brain injury.
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spelling pubmed-43541152015-03-24 Transplantation of autologous bone marrow-derived mesenchymal stem cells for traumatic brain injury☆ Jiang, Jindou Bu, Xingyao Liu, Meng Cheng, Peixun Neural Regen Res Research and Report: Stem Cells and Neuroregenration Results from the present study demonstrated that transplantation of autologous bone marrow-derived mesenchymal stem cells into the lesion site in rat brain significantly ameliorated brain tissue pathological changes and brain edema, attenuated glial cell proliferation, and increased brain-derived neurotrophic factor expression. In addition, the number of cells double-labeled for 5-bromodeoxyuridine/glial fibrillary acidic protein and cells expressing nestin increased. Finally, blood vessels were newly generated, and the rats exhibited improved motor and cognitive functions. These results suggested that transplantation of autologous bone marrow-derived mesenchymal stem cells promoted brain remodeling and improved neurological functions following traumatic brain injury. Medknow Publications & Media Pvt Ltd 2012-01-05 /pmc/articles/PMC4354115/ /pubmed/25806058 http://dx.doi.org/10.3969/j.issn.1673-5374.2012.01.008 Text en Copyright: © Neural Regeneration Research http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research and Report: Stem Cells and Neuroregenration
Jiang, Jindou
Bu, Xingyao
Liu, Meng
Cheng, Peixun
Transplantation of autologous bone marrow-derived mesenchymal stem cells for traumatic brain injury☆
title Transplantation of autologous bone marrow-derived mesenchymal stem cells for traumatic brain injury☆
title_full Transplantation of autologous bone marrow-derived mesenchymal stem cells for traumatic brain injury☆
title_fullStr Transplantation of autologous bone marrow-derived mesenchymal stem cells for traumatic brain injury☆
title_full_unstemmed Transplantation of autologous bone marrow-derived mesenchymal stem cells for traumatic brain injury☆
title_short Transplantation of autologous bone marrow-derived mesenchymal stem cells for traumatic brain injury☆
title_sort transplantation of autologous bone marrow-derived mesenchymal stem cells for traumatic brain injury☆
topic Research and Report: Stem Cells and Neuroregenration
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4354115/
https://www.ncbi.nlm.nih.gov/pubmed/25806058
http://dx.doi.org/10.3969/j.issn.1673-5374.2012.01.008
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AT liumeng transplantationofautologousbonemarrowderivedmesenchymalstemcellsfortraumaticbraininjury
AT chengpeixun transplantationofautologousbonemarrowderivedmesenchymalstemcellsfortraumaticbraininjury

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