Altered expression of metabotropic glutamate receptor 1 alpha after acute diffuse brain injury: Effect of the competitive antagonist 1-aminoindan-1, 5-dicarboxylic acid☆

The diffuse brain injury model was conducted in Sprague-Dawley rats, according to Marmarou's free-fall attack. The water content in brain tissue, expression of metabotropic glutamate receptor 1α mRNA and protein were significantly increased after injury, reached a peak at 24 hours, and then gra...

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Autores principales: Cao, Fei, Chen, Mantao, Li, Gu, Ye, Ke, Huang, Xin, Zheng, Xiujue
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2012
Materias:
Technique and Method: Brain Injury and Neuroregeneration
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4354126/
https://www.ncbi.nlm.nih.gov/pubmed/25767486
http://dx.doi.org/10.3969/j.issn.1673-5374.2012.02.007
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author Cao, Fei
Chen, Mantao
Li, Gu
Ye, Ke
Huang, Xin
Zheng, Xiujue
author_facet Cao, Fei
Chen, Mantao
Li, Gu
Ye, Ke
Huang, Xin
Zheng, Xiujue
author_sort Cao, Fei
collection PubMed
description The diffuse brain injury model was conducted in Sprague-Dawley rats, according to Marmarou's free-fall attack. The water content in brain tissue, expression of metabotropic glutamate receptor 1α mRNA and protein were significantly increased after injury, reached a peak at 24 hours, and then gradually decreased. After treatment with the competitive antagonist of metabotropic glutamate receptor 1α, (RS)-1-aminoindan-1, 5-dicarboxylic acid, the water content of brain tissues decreased between 12–72 hours after injury, and neurological behaviors improved at 2 weeks. These experimental findings suggest that the 1-aminoindan-1, 5-dicarboxylic acid may result in marked neuroprotection against diffuse brain injury.
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spelling pubmed-43541262015-03-12 Altered expression of metabotropic glutamate receptor 1 alpha after acute diffuse brain injury: Effect of the competitive antagonist 1-aminoindan-1, 5-dicarboxylic acid☆ Cao, Fei Chen, Mantao Li, Gu Ye, Ke Huang, Xin Zheng, Xiujue Neural Regen Res Technique and Method: Brain Injury and Neuroregeneration The diffuse brain injury model was conducted in Sprague-Dawley rats, according to Marmarou's free-fall attack. The water content in brain tissue, expression of metabotropic glutamate receptor 1α mRNA and protein were significantly increased after injury, reached a peak at 24 hours, and then gradually decreased. After treatment with the competitive antagonist of metabotropic glutamate receptor 1α, (RS)-1-aminoindan-1, 5-dicarboxylic acid, the water content of brain tissues decreased between 12–72 hours after injury, and neurological behaviors improved at 2 weeks. These experimental findings suggest that the 1-aminoindan-1, 5-dicarboxylic acid may result in marked neuroprotection against diffuse brain injury. Medknow Publications & Media Pvt Ltd 2012-01-15 /pmc/articles/PMC4354126/ /pubmed/25767486 http://dx.doi.org/10.3969/j.issn.1673-5374.2012.02.007 Text en Copyright: © Neural Regeneration Research http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Technique and Method: Brain Injury and Neuroregeneration
Cao, Fei
Chen, Mantao
Li, Gu
Ye, Ke
Huang, Xin
Zheng, Xiujue
Altered expression of metabotropic glutamate receptor 1 alpha after acute diffuse brain injury: Effect of the competitive antagonist 1-aminoindan-1, 5-dicarboxylic acid☆
title Altered expression of metabotropic glutamate receptor 1 alpha after acute diffuse brain injury: Effect of the competitive antagonist 1-aminoindan-1, 5-dicarboxylic acid☆
title_full Altered expression of metabotropic glutamate receptor 1 alpha after acute diffuse brain injury: Effect of the competitive antagonist 1-aminoindan-1, 5-dicarboxylic acid☆
title_fullStr Altered expression of metabotropic glutamate receptor 1 alpha after acute diffuse brain injury: Effect of the competitive antagonist 1-aminoindan-1, 5-dicarboxylic acid☆
title_full_unstemmed Altered expression of metabotropic glutamate receptor 1 alpha after acute diffuse brain injury: Effect of the competitive antagonist 1-aminoindan-1, 5-dicarboxylic acid☆
title_short Altered expression of metabotropic glutamate receptor 1 alpha after acute diffuse brain injury: Effect of the competitive antagonist 1-aminoindan-1, 5-dicarboxylic acid☆
title_sort altered expression of metabotropic glutamate receptor 1 alpha after acute diffuse brain injury: effect of the competitive antagonist 1-aminoindan-1, 5-dicarboxylic acid☆
topic Technique and Method: Brain Injury and Neuroregeneration
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4354126/
https://www.ncbi.nlm.nih.gov/pubmed/25767486
http://dx.doi.org/10.3969/j.issn.1673-5374.2012.02.007
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