Rizatriptan benzoate influences the endogenous pain modulatory system in a rat model of migraine☆

The present study utilized a nitroglycerin-induced rat model of migraine to detect the effects of rizatriptan benzoate on proenkephalin and substance P gene expression in the midbrain using real-time quantitative polymerase chain reaction and investigate whether rizatriptan benzoate can regulate the...

Descripción completa

Detalles Bibliográficos
Autores principales: Yao, Gang, Man, Yuhong, Luo, Xiangdan, Yu, Tingmin, Ji, Lin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2012
Materias:
Technique and Method: Brain Injury and Neuroregeneration
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4354128/
https://www.ncbi.nlm.nih.gov/pubmed/25767488
http://dx.doi.org/10.3969/j.issn.1673-5374.2012.02.009
_version_ 1782360709592514560
author Yao, Gang
Man, Yuhong
Luo, Xiangdan
Yu, Tingmin
Ji, Lin
author_facet Yao, Gang
Man, Yuhong
Luo, Xiangdan
Yu, Tingmin
Ji, Lin
author_sort Yao, Gang
collection PubMed
description The present study utilized a nitroglycerin-induced rat model of migraine to detect the effects of rizatriptan benzoate on proenkephalin and substance P gene expression in the midbrain using real-time quantitative polymerase chain reaction and investigate whether rizatriptan benzoate can regulate the endogenous pain modulatory system. The results showed that rizatriptan benzoate significantly reduced expression of the mRNAs for proenkephalin and substance P. Rizatriptan benzoate may inhibit the analgesic effect of the endogenous pain modulatory system.
format Online
Article
Text
id pubmed-4354128
institution National Center for Biotechnology Information
language English
publishDate 2012
publisher Medknow Publications & Media Pvt Ltd
record_format MEDLINE/PubMed
spelling pubmed-43541282015-03-12 Rizatriptan benzoate influences the endogenous pain modulatory system in a rat model of migraine☆ Yao, Gang Man, Yuhong Luo, Xiangdan Yu, Tingmin Ji, Lin Neural Regen Res Technique and Method: Brain Injury and Neuroregeneration The present study utilized a nitroglycerin-induced rat model of migraine to detect the effects of rizatriptan benzoate on proenkephalin and substance P gene expression in the midbrain using real-time quantitative polymerase chain reaction and investigate whether rizatriptan benzoate can regulate the endogenous pain modulatory system. The results showed that rizatriptan benzoate significantly reduced expression of the mRNAs for proenkephalin and substance P. Rizatriptan benzoate may inhibit the analgesic effect of the endogenous pain modulatory system. Medknow Publications & Media Pvt Ltd 2012-01-15 /pmc/articles/PMC4354128/ /pubmed/25767488 http://dx.doi.org/10.3969/j.issn.1673-5374.2012.02.009 Text en Copyright: © Neural Regeneration Research http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Technique and Method: Brain Injury and Neuroregeneration
Yao, Gang
Man, Yuhong
Luo, Xiangdan
Yu, Tingmin
Ji, Lin
Rizatriptan benzoate influences the endogenous pain modulatory system in a rat model of migraine☆
title Rizatriptan benzoate influences the endogenous pain modulatory system in a rat model of migraine☆
title_full Rizatriptan benzoate influences the endogenous pain modulatory system in a rat model of migraine☆
title_fullStr Rizatriptan benzoate influences the endogenous pain modulatory system in a rat model of migraine☆
title_full_unstemmed Rizatriptan benzoate influences the endogenous pain modulatory system in a rat model of migraine☆
title_short Rizatriptan benzoate influences the endogenous pain modulatory system in a rat model of migraine☆
title_sort rizatriptan benzoate influences the endogenous pain modulatory system in a rat model of migraine☆
topic Technique and Method: Brain Injury and Neuroregeneration
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4354128/
https://www.ncbi.nlm.nih.gov/pubmed/25767488
http://dx.doi.org/10.3969/j.issn.1673-5374.2012.02.009
work_keys_str_mv AT yaogang rizatriptanbenzoateinfluencestheendogenouspainmodulatorysysteminaratmodelofmigraine
AT manyuhong rizatriptanbenzoateinfluencestheendogenouspainmodulatorysysteminaratmodelofmigraine
AT luoxiangdan rizatriptanbenzoateinfluencestheendogenouspainmodulatorysysteminaratmodelofmigraine
AT yutingmin rizatriptanbenzoateinfluencestheendogenouspainmodulatorysysteminaratmodelofmigraine
AT jilin rizatriptanbenzoateinfluencestheendogenouspainmodulatorysysteminaratmodelofmigraine

Ejemplares similares