The role of autophagy in Parkinson's disease☆

Although Parkinson's disease is the most common neurodegenerative movement disorder, the mechanisms of pathogenesis remain poorly understood. Recent findings have shown that deregulation of the autophagy-lysosome pathway is involved in the pathogenesis of Parkinson's disease. This review s...

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Detalles Bibliográficos
Autores principales: Zhang, Lei, Dong, Yaru, Xu, Xiaoheng, Xu, Zhong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2012
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4354131/
https://www.ncbi.nlm.nih.gov/pubmed/25767490
http://dx.doi.org/10.3969/j.issn.1673-5374.2012.02.011
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author Zhang, Lei
Dong, Yaru
Xu, Xiaoheng
Xu, Zhong
author_facet Zhang, Lei
Dong, Yaru
Xu, Xiaoheng
Xu, Zhong
author_sort Zhang, Lei
collection PubMed
description Although Parkinson's disease is the most common neurodegenerative movement disorder, the mechanisms of pathogenesis remain poorly understood. Recent findings have shown that deregulation of the autophagy-lysosome pathway is involved in the pathogenesis of Parkinson's disease. This review summarizes the most recent findings and discusses the unique role of the autophagy-lysosome pathway in Parkinson's disease to highlight the possibility of Parkinson's disease treatment strategies that incorporate autophagy-lysosome pathway modulation.
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spelling pubmed-43541312015-03-12 The role of autophagy in Parkinson's disease☆ Zhang, Lei Dong, Yaru Xu, Xiaoheng Xu, Zhong Neural Regen Res Review Although Parkinson's disease is the most common neurodegenerative movement disorder, the mechanisms of pathogenesis remain poorly understood. Recent findings have shown that deregulation of the autophagy-lysosome pathway is involved in the pathogenesis of Parkinson's disease. This review summarizes the most recent findings and discusses the unique role of the autophagy-lysosome pathway in Parkinson's disease to highlight the possibility of Parkinson's disease treatment strategies that incorporate autophagy-lysosome pathway modulation. Medknow Publications & Media Pvt Ltd 2012-01-15 /pmc/articles/PMC4354131/ /pubmed/25767490 http://dx.doi.org/10.3969/j.issn.1673-5374.2012.02.011 Text en Copyright: © Neural Regeneration Research http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review
Zhang, Lei
Dong, Yaru
Xu, Xiaoheng
Xu, Zhong
The role of autophagy in Parkinson's disease☆
title The role of autophagy in Parkinson's disease☆
title_full The role of autophagy in Parkinson's disease☆
title_fullStr The role of autophagy in Parkinson's disease☆
title_full_unstemmed The role of autophagy in Parkinson's disease☆
title_short The role of autophagy in Parkinson's disease☆
title_sort role of autophagy in parkinson's disease☆
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4354131/
https://www.ncbi.nlm.nih.gov/pubmed/25767490
http://dx.doi.org/10.3969/j.issn.1673-5374.2012.02.011
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