Influence of RNA interference on the mitochondrial subcellular localization of alpha-synuclein and on the formation of Lewy body-like inclusions in the cytoplasm of human embryonic kidney 293 cells induced by the overexpression of alpha-synuclein☆

The specific and effective α-synuclein RNA interference (RNAi) plasmids, and the α-synuclein-pEGFP recombinant plasmids were co-transfected into human embryonic kidney 293 (HEK293) cells using the lipofectamine method. Using an inverted fluorescence microscope, α-synuclein proteins were observed to...

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Detalles Bibliográficos
Autores principales: Chen, Tao, Liao, Xiaoping, Wen, Guoqiang, Deng, Yidong, Guo, Min, Long, Zhigang, Ouyang, Feng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2012
Materias:
Research and Report: Neurodegenerative Diseases and Neuroregeneration
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4354134/
https://www.ncbi.nlm.nih.gov/pubmed/25767480
http://dx.doi.org/10.3969/j.issn.1673-5374.2012.02.001

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