Cargando…

Effects of ultrafine particles on the allergic inflammation in the lung of asthmatics: results of a double-blinded randomized cross-over clinical pilot study

BACKGROUND: Epidemiological and experimental studies suggest that exposure to ultrafine particles (UFP) might aggravate the allergic inflammation of the lung in asthmatics. METHODS: We exposed 12 allergic asthmatics in two subgroups in a double-blinded randomized cross-over design, first to freshly...

Descripción completa

Detalles Bibliográficos
Autores principales:	Schaumann, Frank, Frömke, Cornelia, Dijkstra, Dorothea, Alessandrini, Francesca, Windt, Horst, Karg, Erwin, Müller, Meike, Winkler, Carla, Braun, Armin, Koch, Armin, Hohlfeld, Jens Michael, Behrendt, Heidrun, Schmid, Otmar, Koch, Wolfgang, Schulz, Holger, Krug, Norbert
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2014
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4354282/ https://www.ncbi.nlm.nih.gov/pubmed/25204642 http://dx.doi.org/10.1186/s12989-014-0039-3

Ejemplares similares

Effects of ultrafine particles-induced oxidative stress on Clara cells in allergic lung inflammation
por: Alessandrini, Francesca, et al.
Publicado: (2010)

Ultrafine particles affect the balance of endogenous pro- and anti-inflammatory lipid mediators in the lung: in-vitro and in-vivo studies
por: Beck-Speier, Ingrid, et al.
Publicado: (2012)

Impact of endobronchial allergen provocation on macrophage phenotype in asthmatics
por: Winkler, Carla, et al.
Publicado: (2014)

Poster 1007: Universal allergen particle generation for inhaled allergen challenges in the fraunhofer environmental challenge chamber (ECC)
por: Hohlfeld, Jens M, et al.
Publicado: (2014)

A multicenter, randomized, open-labeled study to steer immunosuppressive and antiviral therapy by measurement of virus (CMV, ADV, HSV)-specific T cells in addition to determination of trough levels of immunosuppressants in pediatric kidney allograft recipients (IVIST01-trial): study protocol for a randomized controlled trial
por: Ahlenstiel-Grunow, Thurid, et al.
Publicado: (2014)

Ultrafine particles and ozone perturb norepinephrine clearance rather than centrally generated sympathetic activity in humans
por: Heusser, Karsten, et al.
Publicado: (2019)

The Effect of Ventilation, Age, and Asthmatic Condition on Ultrafine Particle Deposition in Children
por: Olvera, Hector A., et al.
Publicado: (2012)

Evaluation of an environmental exposure unit (EEU) for controlled inhalation studies with pollen allergens()
por: Hohlfeld, J.M., et al.
Publicado: (2003)

Plasmacytoid dendritic cells downregulate the allergen induced T cell proliferation in a human in vitro allergy model
por: Schaumann, Frank, et al.
Publicado: (2013)

Surgical smoke and ultrafine particles
por: Brüske-Hohlfeld, Irene, et al.
Publicado: (2008)

Pulmonary and systemic distribution of inhaled ultrafine silver particles in rats.
por: Takenaka, S, et al.
Publicado: (2001)

Instillation of Six Different Ultrafine Carbon Particles Indicates a Surface Area Threshold Dose for Acute Lung Inflammation in Mice
por: Stoeger, Tobias, et al.
Publicado: (2006)

Effect of Acute Ozone Induced Airway Inflammation on Human Sympathetic Nerve Traffic: A Randomized, Placebo Controlled, Crossover Study
por: Tank, Jens, et al.
Publicado: (2011)

Exposure to ultrafine carbon particles at levels below detectable pulmonary inflammation affects cardiovascular performance in spontaneously hypertensive rats
por: Upadhyay, Swapna, et al.
Publicado: (2008)

Allergen particle binding by human primary bronchial epithelial cells is modulated by surfactant protein D
por: Schleh, Carsten, et al.
Publicado: (2010)

Deducing in Vivo Toxicity of Combustion-Derived Nanoparticles from a Cell-Free Oxidative Potency Assay and Metabolic Activation of Organic Compounds
por: Stoeger, Tobias, et al.
Publicado: (2009)

Low-dose endotoxin inhalation in healthy volunteers - a challenge model for early clinical drug development
por: Janssen, Ole, et al.
Publicado: (2013)

Agglomerates of ultrafine particles of elemental carbon and TiO2 induce generation of lipid mediators in alveolar macrophages.
por: Beck-Speier, I, et al.
Publicado: (2001)

Invasive versus noninvasive measurement of allergic and cholinergic airway responsiveness in mice
por: Glaab, Thomas, et al.
Publicado: (2005)

Nonparametric relevance-shifted multiple testing procedures for the analysis of high-dimensional multivariate data with small sample sizes
por: Frömke, Cornelia, et al.
Publicado: (2008)

Translocation of Ultrafine Particles
por: Nemmar, Abderrahim, et al.
Publicado: (2006)

Ultrafine particles in the atmosphere
por: Brown, L M, et al.
Publicado: (2003)

Does it help that efficacy has been proven once we start discussing (added) benefit?
por: Koch, Armin, et al.
Publicado: (2015)

Commentary on: Subgroup analysis and interpretation for phase 3 confirmatory trials: White Paper of the EFSPI/PSI working group on subgroup analysis by Dane, Spencer, Rosenkranz, Lipkovich, and Parke
por: Hemmings, Robert, et al.
Publicado: (2019)

COVID-19 hits a trial: Arguments against hastily deviating from the plan
por: Großhennig, Anika, et al.
Publicado: (2020)

Inflammatory and Oxidative Stress Responses of an Alveolar Epithelial Cell Line to Airborne Zinc Oxide Nanoparticles at the Air-Liquid Interface: A Comparison with Conventional, Submerged Cell-Culture Conditions
por: Lenz, Anke-Gabriele, et al.
Publicado: (2013)

Airway hyper-responsiveness in lipopolysaccharide-challenged common marmosets (Callithrix jacchus)
por: Curths, Christoph, et al.
Publicado: (2013)

Prostaglandin D(2) metabolites activate asthmatic patient-derived type 2 innate lymphoid cells and eosinophils via the DP(2) receptor
por: Carstensen, Saskia, et al.
Publicado: (2021)

Epidemiology and antifungal resistance in invasive candidiasis
por: Rodloff, AC, et al.
Publicado: (2011)

Correction
por: Traidl-Hoffmann, Claudia, et al.
Publicado: (2005)

Pollen-associated phytoprostanes inhibit dendritic cell interleukin-12 production and augment T helper type 2 cell polarization
por: Traidl-Hoffmann, Claudia, et al.
Publicado: (2005)

The health effects of ultrafine particles
por: Schraufnagel, Dean E.
Publicado: (2020)

A dose-controlled system for air-liquid interface cell exposure and application to zinc oxide nanoparticles
por: Lenz, Anke Gabriele, et al.
Publicado: (2009)

Identification of a lineage specific zinc responsive genomic island in Mycobacterium avium ssp. paratuberculosis
por: Eckelt, Elke, et al.
Publicado: (2014)

Ultrafine Aerosol Particle Sizer Based on Piezoresistive Microcantilever Resonators with Integrated Air-Flow Channel
por: Bertke, Maik, et al.
Publicado: (2021)

A phase II trial comparing pazopanib with doxorubicin as first-line treatment in elderly patients with metastatic or advanced soft tissue sarcoma (EPAZ): study protocol for a randomized controlled trial
por: Karch, Annika, et al.
Publicado: (2016)

New research strategy with ambiguous implications: A comment on “Planning future studies based on the conditional power of a meta‐analysis”
por: Weber, Kristina, et al.
Publicado: (2018)

How to use prior knowledge and still give new data a chance?
por: Weber, Kristina, et al.
Publicado: (2018)

Commentary: On the levels of patient selection in registry-based randomized controlled trials
por: Lasch, Florian, et al.
Publicado: (2019)

Empirical evaluation of the implementation of the EMA guideline on missing data in confirmatory clinical trials: Specification of mixed models for longitudinal data in study protocols
por: Häckl, Sebastian, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_7guou5k6apl5e2918jr131gsj7