Rb and FZR1/Cdh1 determine CDK4/6-cyclin D requirement in C. elegans and human cancer cells

Cyclin-dependent kinases 4 and 6 (CDK4/6) in complex with D-type cyclins promote cell cycle entry. Most human cancers contain overactive CDK4/6-cyclin D, and CDK4/6-specific inhibitors are promising anti-cancer therapeutics. Here, we investigate the critical functions of CDK4/6-cyclin D kinases, sta...

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Detalles Bibliográficos
Autores principales: The, Inge, Ruijtenberg, Suzan, Bouchet, Benjamin P., Cristobal, Alba, Prinsen, Martine B. W., van Mourik, Tim, Koreth, John, Xu, Huihong, Heck, Albert J. R., Akhmanova, Anna, Cuppen, Edwin, Boxem, Mike, Muñoz, Javier, van den Heuvel, Sander
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Pub. Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4354291/
https://www.ncbi.nlm.nih.gov/pubmed/25562820
http://dx.doi.org/10.1038/ncomms6906

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