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Neural correlates of high-risk behavior tendencies and impulsivity in an emotional Go/NoGo fMRI task
Improved neuroscientific understanding of high-risk behaviors such as alcohol binging, drug use, and unsafe sex will lead to therapeutic advances for high-risk groups. High-risk behavior often occurs in an emotionally-charged context, and behavioral inhibition and emotion regulation play important r...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4354310/ https://www.ncbi.nlm.nih.gov/pubmed/25805975 http://dx.doi.org/10.3389/fnsys.2015.00024 |
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author | Brown, Matthew R. G. Benoit, James R. A. Juhás, Michal Lebel, R. M. MacKay, Marnie Dametto, Ericson Silverstone, Peter H. Dolcos, Florin Dursun, Serdar M. Greenshaw, Andrew J. |
author_facet | Brown, Matthew R. G. Benoit, James R. A. Juhás, Michal Lebel, R. M. MacKay, Marnie Dametto, Ericson Silverstone, Peter H. Dolcos, Florin Dursun, Serdar M. Greenshaw, Andrew J. |
author_sort | Brown, Matthew R. G. |
collection | PubMed |
description | Improved neuroscientific understanding of high-risk behaviors such as alcohol binging, drug use, and unsafe sex will lead to therapeutic advances for high-risk groups. High-risk behavior often occurs in an emotionally-charged context, and behavioral inhibition and emotion regulation play important roles in risk-related decision making. High impulsivity is an important potential contributor to high-risk behavior tendencies. We explored the relationships between high-risk behavior tendencies, impulsivity, and fMRI brain activations in an emotional Go/NoGo task. This task presented emotional distractor pictures (aversive vs. neutral) simultaneously with Go/NoGo stimuli (square vs. circle) that required a button press or withholding of the press, respectively. Participants' risk behavior tendencies were assessed with the Cognitive Appraisal of Risky Events (CARE) scale. The Barratt Impulsivity Scale 11 (BIS) was used to assess participant impulsivity. Individuals with higher CARE risk scores exhibited reduced activation related to response inhibition (NoGo−Go) in right orbital frontal cortex (OFC) and ventromedial prefrontal cortex. These regions did not show a significant relationship with impulsivity scores. Conversely, more impulsive individuals showed reduced emotion-related activity (aversive−neutral distractors) in dorsomedial prefrontal cortex, perigenual anterior cingulate cortex, and right posterior OFC. There were distinct neural correlates of high-risk behavior tendency and impulsivity in terms of brain activity in the emotional Go/NoGo task. This dissociation supports the conception of high-risk behavior tendency as a distinct construct from that of impulsivity. Our results suggest that treatment for high-risk behavior may be more effective with a nuanced approach that does not conflate high impulsivity necessarily with high-risk behavior tendencies. |
format | Online Article Text |
id | pubmed-4354310 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-43543102015-03-24 Neural correlates of high-risk behavior tendencies and impulsivity in an emotional Go/NoGo fMRI task Brown, Matthew R. G. Benoit, James R. A. Juhás, Michal Lebel, R. M. MacKay, Marnie Dametto, Ericson Silverstone, Peter H. Dolcos, Florin Dursun, Serdar M. Greenshaw, Andrew J. Front Syst Neurosci Neuroscience Improved neuroscientific understanding of high-risk behaviors such as alcohol binging, drug use, and unsafe sex will lead to therapeutic advances for high-risk groups. High-risk behavior often occurs in an emotionally-charged context, and behavioral inhibition and emotion regulation play important roles in risk-related decision making. High impulsivity is an important potential contributor to high-risk behavior tendencies. We explored the relationships between high-risk behavior tendencies, impulsivity, and fMRI brain activations in an emotional Go/NoGo task. This task presented emotional distractor pictures (aversive vs. neutral) simultaneously with Go/NoGo stimuli (square vs. circle) that required a button press or withholding of the press, respectively. Participants' risk behavior tendencies were assessed with the Cognitive Appraisal of Risky Events (CARE) scale. The Barratt Impulsivity Scale 11 (BIS) was used to assess participant impulsivity. Individuals with higher CARE risk scores exhibited reduced activation related to response inhibition (NoGo−Go) in right orbital frontal cortex (OFC) and ventromedial prefrontal cortex. These regions did not show a significant relationship with impulsivity scores. Conversely, more impulsive individuals showed reduced emotion-related activity (aversive−neutral distractors) in dorsomedial prefrontal cortex, perigenual anterior cingulate cortex, and right posterior OFC. There were distinct neural correlates of high-risk behavior tendency and impulsivity in terms of brain activity in the emotional Go/NoGo task. This dissociation supports the conception of high-risk behavior tendency as a distinct construct from that of impulsivity. Our results suggest that treatment for high-risk behavior may be more effective with a nuanced approach that does not conflate high impulsivity necessarily with high-risk behavior tendencies. Frontiers Media S.A. 2015-03-10 /pmc/articles/PMC4354310/ /pubmed/25805975 http://dx.doi.org/10.3389/fnsys.2015.00024 Text en Copyright © 2015 Brown, Benoit, Juhás, Lebel, MacKay, Dametto, Silverstone, Dolcos, Dursun and Greenshaw. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Neuroscience Brown, Matthew R. G. Benoit, James R. A. Juhás, Michal Lebel, R. M. MacKay, Marnie Dametto, Ericson Silverstone, Peter H. Dolcos, Florin Dursun, Serdar M. Greenshaw, Andrew J. Neural correlates of high-risk behavior tendencies and impulsivity in an emotional Go/NoGo fMRI task |
title | Neural correlates of high-risk behavior tendencies and impulsivity in an emotional Go/NoGo fMRI task |
title_full | Neural correlates of high-risk behavior tendencies and impulsivity in an emotional Go/NoGo fMRI task |
title_fullStr | Neural correlates of high-risk behavior tendencies and impulsivity in an emotional Go/NoGo fMRI task |
title_full_unstemmed | Neural correlates of high-risk behavior tendencies and impulsivity in an emotional Go/NoGo fMRI task |
title_short | Neural correlates of high-risk behavior tendencies and impulsivity in an emotional Go/NoGo fMRI task |
title_sort | neural correlates of high-risk behavior tendencies and impulsivity in an emotional go/nogo fmri task |
topic | Neuroscience |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4354310/ https://www.ncbi.nlm.nih.gov/pubmed/25805975 http://dx.doi.org/10.3389/fnsys.2015.00024 |
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