Galangin (3,5,7-Trihydroxyflavone) Shields Human Keratinocytes from Ultraviolet B-Induced Oxidative Stress

Most skin damage caused by ultraviolet B (UVB) radiation is owing to the generation of reactive oxygen species. Phytochemicals can act as antioxidants against UVB-induced oxidative stress. This study investigated the protective effects of the flavone galangin against UVB-induced oxidative damage in...

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Autores principales: Madduma Hewage, Susara Ruwan Kumara, Piao, Mei Jing, Kim, Ki Cheon, Cha, Ji Won, Han, Xia, Choi, Yung Hyun, Chae, Sungwook, Hyun, Jin Won
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Korean Society of Applied Pharmacology 2015
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4354318/
https://www.ncbi.nlm.nih.gov/pubmed/25767685
http://dx.doi.org/10.4062/biomolther.2014.130
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author Madduma Hewage, Susara Ruwan Kumara
Piao, Mei Jing
Kim, Ki Cheon
Cha, Ji Won
Han, Xia
Choi, Yung Hyun
Chae, Sungwook
Hyun, Jin Won
author_facet Madduma Hewage, Susara Ruwan Kumara
Piao, Mei Jing
Kim, Ki Cheon
Cha, Ji Won
Han, Xia
Choi, Yung Hyun
Chae, Sungwook
Hyun, Jin Won
author_sort Madduma Hewage, Susara Ruwan Kumara
collection PubMed
description Most skin damage caused by ultraviolet B (UVB) radiation is owing to the generation of reactive oxygen species. Phytochemicals can act as antioxidants against UVB-induced oxidative stress. This study investigated the protective effects of the flavone galangin against UVB-induced oxidative damage in human keratinocytes. Galangin efficiently scavenged free radicals and reduced UVB-induced damage to cellular macromolecules, such as DNA, lipids, and proteins. Furthermore, galangin rescued cells undergoing apoptosis induced by UVB radiation via recovering mitochondrial polarization and down-regulating apoptotic proteins. These results showed that galangin protects human keratinocytes against UVB radiation-induced cellular damage and apoptosis via its antioxidant effects.
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spelling pubmed-43543182015-03-12 Galangin (3,5,7-Trihydroxyflavone) Shields Human Keratinocytes from Ultraviolet B-Induced Oxidative Stress Madduma Hewage, Susara Ruwan Kumara Piao, Mei Jing Kim, Ki Cheon Cha, Ji Won Han, Xia Choi, Yung Hyun Chae, Sungwook Hyun, Jin Won Biomol Ther (Seoul) Original Article Most skin damage caused by ultraviolet B (UVB) radiation is owing to the generation of reactive oxygen species. Phytochemicals can act as antioxidants against UVB-induced oxidative stress. This study investigated the protective effects of the flavone galangin against UVB-induced oxidative damage in human keratinocytes. Galangin efficiently scavenged free radicals and reduced UVB-induced damage to cellular macromolecules, such as DNA, lipids, and proteins. Furthermore, galangin rescued cells undergoing apoptosis induced by UVB radiation via recovering mitochondrial polarization and down-regulating apoptotic proteins. These results showed that galangin protects human keratinocytes against UVB radiation-induced cellular damage and apoptosis via its antioxidant effects. The Korean Society of Applied Pharmacology 2015-03 2015-03-01 /pmc/articles/PMC4354318/ /pubmed/25767685 http://dx.doi.org/10.4062/biomolther.2014.130 Text en Copyright © 2015 The Korean Society of Applied Pharmacology http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Madduma Hewage, Susara Ruwan Kumara
Piao, Mei Jing
Kim, Ki Cheon
Cha, Ji Won
Han, Xia
Choi, Yung Hyun
Chae, Sungwook
Hyun, Jin Won
Galangin (3,5,7-Trihydroxyflavone) Shields Human Keratinocytes from Ultraviolet B-Induced Oxidative Stress
title Galangin (3,5,7-Trihydroxyflavone) Shields Human Keratinocytes from Ultraviolet B-Induced Oxidative Stress
title_full Galangin (3,5,7-Trihydroxyflavone) Shields Human Keratinocytes from Ultraviolet B-Induced Oxidative Stress
title_fullStr Galangin (3,5,7-Trihydroxyflavone) Shields Human Keratinocytes from Ultraviolet B-Induced Oxidative Stress
title_full_unstemmed Galangin (3,5,7-Trihydroxyflavone) Shields Human Keratinocytes from Ultraviolet B-Induced Oxidative Stress
title_short Galangin (3,5,7-Trihydroxyflavone) Shields Human Keratinocytes from Ultraviolet B-Induced Oxidative Stress
title_sort galangin (3,5,7-trihydroxyflavone) shields human keratinocytes from ultraviolet b-induced oxidative stress
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4354318/
https://www.ncbi.nlm.nih.gov/pubmed/25767685
http://dx.doi.org/10.4062/biomolther.2014.130
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