TREM2 deficiency eliminates TREM2(+) inflammatory macrophages and ameliorates pathology in Alzheimer’s disease mouse models

Variants in triggering receptor expressed on myeloid cells 2 (TREM2) confer high risk for Alzheimer’s disease (AD) and other neurodegenerative diseases. However, the cell types and mechanisms underlying TREM2’s involvement in neurodegeneration remain to be established. Here, we report that TREM2 is...

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Detalles Bibliográficos
Autores principales: Jay, Taylor R., Miller, Crystal M., Cheng, Paul J., Graham, Leah C., Bemiller, Shane, Broihier, Margaret L., Xu, Guixiang, Margevicius, Daniel, Karlo, J. Colleen, Sousa, Gregory L., Cotleur, Anne C., Butovsky, Oleg, Bekris, Lynn, Staugaitis, Susan M., Leverenz, James B., Pimplikar, Sanjay W., Landreth, Gary E., Howell, Gareth R., Ransohoff, Richard M., Lamb, Bruce T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2015
Materias:
Brief Definitive Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4354365/
https://www.ncbi.nlm.nih.gov/pubmed/25732305
http://dx.doi.org/10.1084/jem.20142322

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