Cargando…

Dysfunctional HCN ion channels in neurological diseases

Hyperpolarization-activated cyclic nucleotide-gated (HCN) channels are expressed as four different isoforms (HCN1-4) in the heart and in the central and peripheral nervous systems. HCN channels are activated by membrane hyperpolarization at voltages close to resting membrane potentials and carry the...

Descripción completa

Detalles Bibliográficos
Autores principales:	DiFrancesco, Jacopo C., DiFrancesco, Dario
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2015
Materias:	Neuroscience
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4354400/ https://www.ncbi.nlm.nih.gov/pubmed/25805968 http://dx.doi.org/10.3389/fncel.2015.00071

Ejemplares similares

Integrated Allosteric Model of Voltage Gating of Hcn Channels
por: Altomare, Claudia, et al.
Publicado: (2001)

Identification of the Molecular Site of Ivabradine Binding to HCN4 Channels
por: Bucchi, Annalisa, et al.
Publicado: (2013)

Funny Current and Cardiac Rhythm: Insights from HCN Knockout and Transgenic Mouse Models
por: Bucchi, Annalisa, et al.
Publicado: (2012)

A Loss-of-Function HCN4 Mutation Associated With Familial Benign Myoclonic Epilepsy in Infancy Causes Increased Neuronal Excitability
por: Campostrini, Giulia, et al.
Publicado: (2018)

Gating movements and ion permeation in HCN4 pacemaker channels
por: Saponaro, Andrea, et al.
Publicado: (2021)

Anti-Aβ Autoantibodies in Amyloid Related Imaging Abnormalities (ARIA): Candidate Biomarker for Immunotherapy in Alzheimer’s Disease and Cerebral Amyloid Angiopathy
por: DiFrancesco, Jacopo C., et al.
Publicado: (2015)

Current-dependent Block of Rabbit Sino-Atrial Node I(f) Channels by Ivabradine
por: Bucchi, Annalisa, et al.
Publicado: (2002)

Comparing pathways for long-term heart rate modulation by the funny current
por: DiFrancesco, Dario
Publicado: (2019)

A Brief History of Pacemaking
por: DiFrancesco, Dario
Publicado: (2020)

Exercise training reduces resting heart rate via downregulation of the funny channel HCN4
por: D’Souza, Alicia, et al.
Publicado: (2014)

A synthetic peptide that prevents cAMP regulation in mammalian hyperpolarization-activated cyclic nucleotide-gated (HCN) channels
por: Saponaro, Andrea, et al.
Publicado: (2018)

Silvio Weidmann: laying the foundations for unravelling the mechanism of heart rhythm
por: DiFrancesco, Dario, et al.
Publicado: (2023)

Alkali metal cations modulate the geometry of different binding sites in HCN4 selectivity filter for permeation or block
por: Krumbach, Jan H., et al.
Publicado: (2023)

Age-Related Changes in Cardiac Autonomic Modulation and Heart Rate Variability in Mice
por: Piantoni, Chiara, et al.
Publicado: (2021)

Neurological soft signs are increased in migraine without aura: relationship with the affective status
por: Tremolizzo, Lucio, et al.
Publicado: (2022)

Developmental Changes in HCN Channel Modulation of Neocortical Layer 1 Interneurons
por: Bohannon, Andrew S., et al.
Publicado: (2018)

Disturbed Processing of Contextual Information in HCN3 Channel Deficient Mice
por: Stieglitz, Marc S., et al.
Publicado: (2018)

Selective Blockade of HCN1/HCN2 Channels as a Potential Pharmacological Strategy Against Pain
por: Dini, Leonardo, et al.
Publicado: (2018)

Hyperpolarization-Activated Cyclic Nucleotide-Gated Ion (HCN) Channels Regulate PC12 Cell Differentiation Toward Sympathetic Neuron
por: Zhong, Li-Ying, et al.
Publicado: (2019)

HCN Channel Modulation of Synaptic Integration in GABAergic Interneurons in Malformed Rat Neocortex
por: Albertson, Asher J., et al.
Publicado: (2017)

Engineering a Ca(++)-Sensitive (Bio)Sensor from the Pore-Module of a Potassium Channel
por: DiFrancesco, Mattia Lorenzo, et al.
Publicado: (2015)

The economics of microgravity research
por: DiFrancesco, Jeanne M, et al.
Publicado: (2015)

The role of HCN channels in peristaltic dysfunction in human ureteral tuberculosis
por: He, Fan, et al.
Publicado: (2018)

Editorial: Ion Channels: Therapeutic Targets for Neurological Disease
por: Hou, Panpan, et al.
Publicado: (2021)

HCN2 channels in the ventral tegmental area regulate behavioral responses to chronic stress
por: Zhong, Peng, et al.
Publicado: (2018)

Endogenous HCN Channels Modulate the Firing Activity of Globus Pallidus Neurons in Parkinsonian Animals
por: Hao, Xiao-Meng, et al.
Publicado: (2019)

HCN Channels and Heart Rate
por: Scicchitano, Pietro, et al.
Publicado: (2012)

Review: HCN Channels in the Heart
por: Depuydt, Anne-Sophie, et al.
Publicado: (2022)

Electromechanical coupling mechanism for activation and inactivation of an HCN channel
por: Dai, Gucan, et al.
Publicado: (2021)

Noise-induced plasticity of KCNQ2/3 and HCN channels underlies vulnerability and resilience to tinnitus
por: Li, Shuang, et al.
Publicado: (2015)

Involvement of HCN Channel in Muscarinic Inhibitory Action on Tonic Firing of Dorsolateral Striatal Cholinergic Interneurons
por: Zhao, Zhe, et al.
Publicado: (2016)

HCN channel-mediated neuromodulation can control action potential velocity and fidelity in central axons
por: Byczkowicz, Niklas, et al.
Publicado: (2019)

Interfacing Graphene-Based Materials With Neural Cells
por: Bramini, Mattia, et al.
Publicado: (2018)

Orchestration of Ion Channels and Transporters in Neocortical Development and Neurological Disorders
por: Bando, Yuki, et al.
Publicado: (2022)

Increased Resting-State Functional Connectivity in the Cingulo-Opercular Cognitive-Control Network after Intervention in Children with Reading Difficulties
por: Horowitz-Kraus, Tzipi, et al.
Publicado: (2015)

Detection of Early Sero-Conversion HIV Infection Using the INSTI(TM) HIV-1 Antibody Point-of-Care Test
por: Cook, Darrel, et al.
Publicado: (2010)

Breakfast consumption is positively associated with nutrient adequacy in Canadian children and adolescents
por: Barr, Susan I., et al.
Publicado: (2014)

Association of breakfast consumption with body mass index and prevalence of overweight/obesity in a nationally-representative survey of Canadian adults
por: Barr, Susan I., et al.
Publicado: (2016)

An N-terminal deletion variant of HCN1 in the epileptic WAG/Rij strain modulates HCN current densities
por: Wemhöner, Konstantin, et al.
Publicado: (2015)

The Proapoptotic Influenza A Virus Protein PB1-F2 Forms a Nonselective Ion Channel
por: Henkel, Michael, et al.
Publicado: (2010)

Cannot write session to /tmp/vufind_sessions/sess_7me9g1qodngflnj8ulg4dpktg1