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Risk factors and effective management of preeclampsia
Preeclampsia, a hypertensive disorder of pregnancy is estimated to complicate 2%–8% of pregnancies and remains a principal cause of maternal and fetal morbidity and mortality. Preeclampsia may present at any gestation but is more commonly encountered in the third trimester. Multiple risk factors hav...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Dove Medical Press
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4354613/ https://www.ncbi.nlm.nih.gov/pubmed/25767405 http://dx.doi.org/10.2147/IBPC.S50641 |
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author | English, Fred A Kenny, Louise C McCarthy, Fergus P |
author_facet | English, Fred A Kenny, Louise C McCarthy, Fergus P |
author_sort | English, Fred A |
collection | PubMed |
description | Preeclampsia, a hypertensive disorder of pregnancy is estimated to complicate 2%–8% of pregnancies and remains a principal cause of maternal and fetal morbidity and mortality. Preeclampsia may present at any gestation but is more commonly encountered in the third trimester. Multiple risk factors have been documented, including: family history, nulliparity, egg donation, diabetes, and obesity. Significant progress has been made in developing tests to predict risk of preeclampsia in pregnancy, but these remain confined to clinical trial settings and center around measuring angiogenic profiles, including placental growth factor or newer tests involving metabolomics. Less progress has been made in developing new treatments and therapeutic targets, and aspirin remains one of the few agents shown to consistently reduce the risk of developing preeclampsia. This review serves to discuss recent advances in risk factor identification, prediction techniques, and management of preeclampsia in antenatal, intrapartum, and postnatal patients. |
format | Online Article Text |
id | pubmed-4354613 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Dove Medical Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-43546132015-03-12 Risk factors and effective management of preeclampsia English, Fred A Kenny, Louise C McCarthy, Fergus P Integr Blood Press Control Review Preeclampsia, a hypertensive disorder of pregnancy is estimated to complicate 2%–8% of pregnancies and remains a principal cause of maternal and fetal morbidity and mortality. Preeclampsia may present at any gestation but is more commonly encountered in the third trimester. Multiple risk factors have been documented, including: family history, nulliparity, egg donation, diabetes, and obesity. Significant progress has been made in developing tests to predict risk of preeclampsia in pregnancy, but these remain confined to clinical trial settings and center around measuring angiogenic profiles, including placental growth factor or newer tests involving metabolomics. Less progress has been made in developing new treatments and therapeutic targets, and aspirin remains one of the few agents shown to consistently reduce the risk of developing preeclampsia. This review serves to discuss recent advances in risk factor identification, prediction techniques, and management of preeclampsia in antenatal, intrapartum, and postnatal patients. Dove Medical Press 2015-03-03 /pmc/articles/PMC4354613/ /pubmed/25767405 http://dx.doi.org/10.2147/IBPC.S50641 Text en © 2015 English et al. This work is published by Dove Medical Press Limited, and licensed under Creative Commons Attribution – Non Commercial (unported, v3.0) License The full terms of the License are available at http://creativecommons.org/licenses/by-nc/3.0/. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. |
spellingShingle | Review English, Fred A Kenny, Louise C McCarthy, Fergus P Risk factors and effective management of preeclampsia |
title | Risk factors and effective management of preeclampsia |
title_full | Risk factors and effective management of preeclampsia |
title_fullStr | Risk factors and effective management of preeclampsia |
title_full_unstemmed | Risk factors and effective management of preeclampsia |
title_short | Risk factors and effective management of preeclampsia |
title_sort | risk factors and effective management of preeclampsia |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4354613/ https://www.ncbi.nlm.nih.gov/pubmed/25767405 http://dx.doi.org/10.2147/IBPC.S50641 |
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