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Risk factors and effective management of preeclampsia

Preeclampsia, a hypertensive disorder of pregnancy is estimated to complicate 2%–8% of pregnancies and remains a principal cause of maternal and fetal morbidity and mortality. Preeclampsia may present at any gestation but is more commonly encountered in the third trimester. Multiple risk factors hav...

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Autores principales: English, Fred A, Kenny, Louise C, McCarthy, Fergus P
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4354613/
https://www.ncbi.nlm.nih.gov/pubmed/25767405
http://dx.doi.org/10.2147/IBPC.S50641
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author English, Fred A
Kenny, Louise C
McCarthy, Fergus P
author_facet English, Fred A
Kenny, Louise C
McCarthy, Fergus P
author_sort English, Fred A
collection PubMed
description Preeclampsia, a hypertensive disorder of pregnancy is estimated to complicate 2%–8% of pregnancies and remains a principal cause of maternal and fetal morbidity and mortality. Preeclampsia may present at any gestation but is more commonly encountered in the third trimester. Multiple risk factors have been documented, including: family history, nulliparity, egg donation, diabetes, and obesity. Significant progress has been made in developing tests to predict risk of preeclampsia in pregnancy, but these remain confined to clinical trial settings and center around measuring angiogenic profiles, including placental growth factor or newer tests involving metabolomics. Less progress has been made in developing new treatments and therapeutic targets, and aspirin remains one of the few agents shown to consistently reduce the risk of developing preeclampsia. This review serves to discuss recent advances in risk factor identification, prediction techniques, and management of preeclampsia in antenatal, intrapartum, and postnatal patients.
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spelling pubmed-43546132015-03-12 Risk factors and effective management of preeclampsia English, Fred A Kenny, Louise C McCarthy, Fergus P Integr Blood Press Control Review Preeclampsia, a hypertensive disorder of pregnancy is estimated to complicate 2%–8% of pregnancies and remains a principal cause of maternal and fetal morbidity and mortality. Preeclampsia may present at any gestation but is more commonly encountered in the third trimester. Multiple risk factors have been documented, including: family history, nulliparity, egg donation, diabetes, and obesity. Significant progress has been made in developing tests to predict risk of preeclampsia in pregnancy, but these remain confined to clinical trial settings and center around measuring angiogenic profiles, including placental growth factor or newer tests involving metabolomics. Less progress has been made in developing new treatments and therapeutic targets, and aspirin remains one of the few agents shown to consistently reduce the risk of developing preeclampsia. This review serves to discuss recent advances in risk factor identification, prediction techniques, and management of preeclampsia in antenatal, intrapartum, and postnatal patients. Dove Medical Press 2015-03-03 /pmc/articles/PMC4354613/ /pubmed/25767405 http://dx.doi.org/10.2147/IBPC.S50641 Text en © 2015 English et al. This work is published by Dove Medical Press Limited, and licensed under Creative Commons Attribution – Non Commercial (unported, v3.0) License The full terms of the License are available at http://creativecommons.org/licenses/by-nc/3.0/. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed.
spellingShingle Review
English, Fred A
Kenny, Louise C
McCarthy, Fergus P
Risk factors and effective management of preeclampsia
title Risk factors and effective management of preeclampsia
title_full Risk factors and effective management of preeclampsia
title_fullStr Risk factors and effective management of preeclampsia
title_full_unstemmed Risk factors and effective management of preeclampsia
title_short Risk factors and effective management of preeclampsia
title_sort risk factors and effective management of preeclampsia
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4354613/
https://www.ncbi.nlm.nih.gov/pubmed/25767405
http://dx.doi.org/10.2147/IBPC.S50641
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