A Leak Pathway for Luminal Protons in Endosomes Drives Oncogenic Signaling in Glioblastoma

Epidermal growth factor receptor (EGFR) signaling is a potent driver of glioblastoma, a malignant and lethal form of brain cancer. Disappointingly, inhibitors targeting receptor tyrosine kinase activity are not clinically effective, and EGFR persists on the plasma membrane to maintain tumor growth a...

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Detalles Bibliográficos
Autores principales: Kondapalli, Kalyan C., Llongueras, Jose P., Capilla-González, Vivian, Prasad, Hari, Hack, Anniesha, Smith, Christopher, Guerrero-Cázares, Hugo, Quiñones-Hinojosa, Alfredo, Rao, Rajini
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4354686/
https://www.ncbi.nlm.nih.gov/pubmed/25662504
http://dx.doi.org/10.1038/ncomms7289

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4354686/
https://www.ncbi.nlm.nih.gov/pubmed/25662504
http://dx.doi.org/10.1038/ncomms7289

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