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The Effects of Uric Acid, Serum Vitamin D3, and Their Interaction on Parkinson's Disease Severity
Objectives. In current study, the relationships between serum vitamin D3 levels and serum UA concentrations as well as their interaction with severity of PD were evaluated in a sample of Iranian PD patients. Method. In a cross sectional study at the one of the main referral hospitals in central regi...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4354724/ https://www.ncbi.nlm.nih.gov/pubmed/25802799 http://dx.doi.org/10.1155/2015/463483 |
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author | Meamar, Rokhsareh Shaabani, Pooria Tabibian, Seyed Reza Aghaye Ghazvini, Mohammad Reza Feizi, Awat |
author_facet | Meamar, Rokhsareh Shaabani, Pooria Tabibian, Seyed Reza Aghaye Ghazvini, Mohammad Reza Feizi, Awat |
author_sort | Meamar, Rokhsareh |
collection | PubMed |
description | Objectives. In current study, the relationships between serum vitamin D3 levels and serum UA concentrations as well as their interaction with severity of PD were evaluated in a sample of Iranian PD patients. Method. In a cross sectional study at the one of the main referral hospitals in central region of Iran, during September to November 2011, 112 patients were recruited. Severity of PD was evaluated sing H&R stages and UPDRS. Results. The Spearman rank correlation coefficient suggests the negative significant association between serum vitamin D3 and UPDRS in patients aged >62 (r = −0.34, P < 0.05). No statistically significant association was observed between the UA levels and severity of PD (represented by H&Y categories) in different levels of serum vitamin D3 not only in total sample but also in separate age and sex groups. The linear regression coefficients suggested positive association between UA and serum vitamin D3 with UPDRSIII scores while negative relationship between UA and serum vitamin D3 interaction with UPDRSIII; however it was only statistically significant in age group ≤62 (P < 0.05). Conclusion. Our study revealed a negative correlation between interaction of serum vitamin D3 and UA with severity of PD; other studies are required to confirm our findings. |
format | Online Article Text |
id | pubmed-4354724 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-43547242015-03-23 The Effects of Uric Acid, Serum Vitamin D3, and Their Interaction on Parkinson's Disease Severity Meamar, Rokhsareh Shaabani, Pooria Tabibian, Seyed Reza Aghaye Ghazvini, Mohammad Reza Feizi, Awat Parkinsons Dis Research Article Objectives. In current study, the relationships between serum vitamin D3 levels and serum UA concentrations as well as their interaction with severity of PD were evaluated in a sample of Iranian PD patients. Method. In a cross sectional study at the one of the main referral hospitals in central region of Iran, during September to November 2011, 112 patients were recruited. Severity of PD was evaluated sing H&R stages and UPDRS. Results. The Spearman rank correlation coefficient suggests the negative significant association between serum vitamin D3 and UPDRS in patients aged >62 (r = −0.34, P < 0.05). No statistically significant association was observed between the UA levels and severity of PD (represented by H&Y categories) in different levels of serum vitamin D3 not only in total sample but also in separate age and sex groups. The linear regression coefficients suggested positive association between UA and serum vitamin D3 with UPDRSIII scores while negative relationship between UA and serum vitamin D3 interaction with UPDRSIII; however it was only statistically significant in age group ≤62 (P < 0.05). Conclusion. Our study revealed a negative correlation between interaction of serum vitamin D3 and UA with severity of PD; other studies are required to confirm our findings. Hindawi Publishing Corporation 2015 2015-02-24 /pmc/articles/PMC4354724/ /pubmed/25802799 http://dx.doi.org/10.1155/2015/463483 Text en Copyright © 2015 Rokhsareh Meamar et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Meamar, Rokhsareh Shaabani, Pooria Tabibian, Seyed Reza Aghaye Ghazvini, Mohammad Reza Feizi, Awat The Effects of Uric Acid, Serum Vitamin D3, and Their Interaction on Parkinson's Disease Severity |
title | The Effects of Uric Acid, Serum Vitamin D3, and Their Interaction on Parkinson's Disease Severity |
title_full | The Effects of Uric Acid, Serum Vitamin D3, and Their Interaction on Parkinson's Disease Severity |
title_fullStr | The Effects of Uric Acid, Serum Vitamin D3, and Their Interaction on Parkinson's Disease Severity |
title_full_unstemmed | The Effects of Uric Acid, Serum Vitamin D3, and Their Interaction on Parkinson's Disease Severity |
title_short | The Effects of Uric Acid, Serum Vitamin D3, and Their Interaction on Parkinson's Disease Severity |
title_sort | effects of uric acid, serum vitamin d3, and their interaction on parkinson's disease severity |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4354724/ https://www.ncbi.nlm.nih.gov/pubmed/25802799 http://dx.doi.org/10.1155/2015/463483 |
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