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The Effects of Uric Acid, Serum Vitamin D3, and Their Interaction on Parkinson's Disease Severity

Objectives. In current study, the relationships between serum vitamin D3 levels and serum UA concentrations as well as their interaction with severity of PD were evaluated in a sample of Iranian PD patients. Method. In a cross sectional study at the one of the main referral hospitals in central regi...

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Autores principales: Meamar, Rokhsareh, Shaabani, Pooria, Tabibian, Seyed Reza, Aghaye Ghazvini, Mohammad Reza, Feizi, Awat
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4354724/
https://www.ncbi.nlm.nih.gov/pubmed/25802799
http://dx.doi.org/10.1155/2015/463483
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author Meamar, Rokhsareh
Shaabani, Pooria
Tabibian, Seyed Reza
Aghaye Ghazvini, Mohammad Reza
Feizi, Awat
author_facet Meamar, Rokhsareh
Shaabani, Pooria
Tabibian, Seyed Reza
Aghaye Ghazvini, Mohammad Reza
Feizi, Awat
author_sort Meamar, Rokhsareh
collection PubMed
description Objectives. In current study, the relationships between serum vitamin D3 levels and serum UA concentrations as well as their interaction with severity of PD were evaluated in a sample of Iranian PD patients. Method. In a cross sectional study at the one of the main referral hospitals in central region of Iran, during September to November 2011, 112 patients were recruited. Severity of PD was evaluated sing H&R stages and UPDRS. Results. The Spearman rank correlation coefficient suggests the negative significant association between serum vitamin D3 and UPDRS in patients aged >62 (r = −0.34, P < 0.05). No statistically significant association was observed between the UA levels and severity of PD (represented by H&Y categories) in different levels of serum vitamin D3 not only in total sample but also in separate age and sex groups. The linear regression coefficients suggested positive association between UA and serum vitamin D3 with UPDRSIII scores while negative relationship between UA and serum vitamin D3 interaction with UPDRSIII; however it was only statistically significant in age group ≤62 (P < 0.05). Conclusion. Our study revealed a negative correlation between interaction of serum vitamin D3 and UA with severity of PD; other studies are required to confirm our findings.
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spelling pubmed-43547242015-03-23 The Effects of Uric Acid, Serum Vitamin D3, and Their Interaction on Parkinson's Disease Severity Meamar, Rokhsareh Shaabani, Pooria Tabibian, Seyed Reza Aghaye Ghazvini, Mohammad Reza Feizi, Awat Parkinsons Dis Research Article Objectives. In current study, the relationships between serum vitamin D3 levels and serum UA concentrations as well as their interaction with severity of PD were evaluated in a sample of Iranian PD patients. Method. In a cross sectional study at the one of the main referral hospitals in central region of Iran, during September to November 2011, 112 patients were recruited. Severity of PD was evaluated sing H&R stages and UPDRS. Results. The Spearman rank correlation coefficient suggests the negative significant association between serum vitamin D3 and UPDRS in patients aged >62 (r = −0.34, P < 0.05). No statistically significant association was observed between the UA levels and severity of PD (represented by H&Y categories) in different levels of serum vitamin D3 not only in total sample but also in separate age and sex groups. The linear regression coefficients suggested positive association between UA and serum vitamin D3 with UPDRSIII scores while negative relationship between UA and serum vitamin D3 interaction with UPDRSIII; however it was only statistically significant in age group ≤62 (P < 0.05). Conclusion. Our study revealed a negative correlation between interaction of serum vitamin D3 and UA with severity of PD; other studies are required to confirm our findings. Hindawi Publishing Corporation 2015 2015-02-24 /pmc/articles/PMC4354724/ /pubmed/25802799 http://dx.doi.org/10.1155/2015/463483 Text en Copyright © 2015 Rokhsareh Meamar et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Meamar, Rokhsareh
Shaabani, Pooria
Tabibian, Seyed Reza
Aghaye Ghazvini, Mohammad Reza
Feizi, Awat
The Effects of Uric Acid, Serum Vitamin D3, and Their Interaction on Parkinson's Disease Severity
title The Effects of Uric Acid, Serum Vitamin D3, and Their Interaction on Parkinson's Disease Severity
title_full The Effects of Uric Acid, Serum Vitamin D3, and Their Interaction on Parkinson's Disease Severity
title_fullStr The Effects of Uric Acid, Serum Vitamin D3, and Their Interaction on Parkinson's Disease Severity
title_full_unstemmed The Effects of Uric Acid, Serum Vitamin D3, and Their Interaction on Parkinson's Disease Severity
title_short The Effects of Uric Acid, Serum Vitamin D3, and Their Interaction on Parkinson's Disease Severity
title_sort effects of uric acid, serum vitamin d3, and their interaction on parkinson's disease severity
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4354724/
https://www.ncbi.nlm.nih.gov/pubmed/25802799
http://dx.doi.org/10.1155/2015/463483
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