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Fighting against kidney diseases with small interfering RNA: opportunities and challenges

The significant improvements in siRNA therapy have been achieved, which have great potential applications in humans. The kidney is a comparatively easy target organ of siRNA therapy due to its unique structural and functional characteristics. Here, we reviewed recent achievements in siRNA design, de...

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Detalles Bibliográficos
Autores principales: Yang, Cheng, Zhang, Chao, Zhao, Zitong, Zhu, Tongyu, Yang, Bin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4354745/
https://www.ncbi.nlm.nih.gov/pubmed/25637948
http://dx.doi.org/10.1186/s12967-015-0387-2
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author Yang, Cheng
Zhang, Chao
Zhao, Zitong
Zhu, Tongyu
Yang, Bin
author_facet Yang, Cheng
Zhang, Chao
Zhao, Zitong
Zhu, Tongyu
Yang, Bin
author_sort Yang, Cheng
collection PubMed
description The significant improvements in siRNA therapy have been achieved, which have great potential applications in humans. The kidney is a comparatively easy target organ of siRNA therapy due to its unique structural and functional characteristics. Here, we reviewed recent achievements in siRNA design, delivery and application with focuses on kidney diseases, in particular kidney transplant-related injuries. In addition, the strategy for increasing serum stability and immune tolerance of siRNA was also discussed. At last, the future challenges of siRNA therapy including organ/tissue/cell-specific delivery and time-controlled silence, as well as selecting therapeutic targets, were addressed as well.
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spelling pubmed-43547452015-03-11 Fighting against kidney diseases with small interfering RNA: opportunities and challenges Yang, Cheng Zhang, Chao Zhao, Zitong Zhu, Tongyu Yang, Bin J Transl Med Review The significant improvements in siRNA therapy have been achieved, which have great potential applications in humans. The kidney is a comparatively easy target organ of siRNA therapy due to its unique structural and functional characteristics. Here, we reviewed recent achievements in siRNA design, delivery and application with focuses on kidney diseases, in particular kidney transplant-related injuries. In addition, the strategy for increasing serum stability and immune tolerance of siRNA was also discussed. At last, the future challenges of siRNA therapy including organ/tissue/cell-specific delivery and time-controlled silence, as well as selecting therapeutic targets, were addressed as well. BioMed Central 2015-02-01 /pmc/articles/PMC4354745/ /pubmed/25637948 http://dx.doi.org/10.1186/s12967-015-0387-2 Text en © Yang et al.; licensee BioMed Central. 2015 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Review
Yang, Cheng
Zhang, Chao
Zhao, Zitong
Zhu, Tongyu
Yang, Bin
Fighting against kidney diseases with small interfering RNA: opportunities and challenges
title Fighting against kidney diseases with small interfering RNA: opportunities and challenges
title_full Fighting against kidney diseases with small interfering RNA: opportunities and challenges
title_fullStr Fighting against kidney diseases with small interfering RNA: opportunities and challenges
title_full_unstemmed Fighting against kidney diseases with small interfering RNA: opportunities and challenges
title_short Fighting against kidney diseases with small interfering RNA: opportunities and challenges
title_sort fighting against kidney diseases with small interfering rna: opportunities and challenges
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4354745/
https://www.ncbi.nlm.nih.gov/pubmed/25637948
http://dx.doi.org/10.1186/s12967-015-0387-2
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