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Fighting against kidney diseases with small interfering RNA: opportunities and challenges
The significant improvements in siRNA therapy have been achieved, which have great potential applications in humans. The kidney is a comparatively easy target organ of siRNA therapy due to its unique structural and functional characteristics. Here, we reviewed recent achievements in siRNA design, de...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4354745/ https://www.ncbi.nlm.nih.gov/pubmed/25637948 http://dx.doi.org/10.1186/s12967-015-0387-2 |
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author | Yang, Cheng Zhang, Chao Zhao, Zitong Zhu, Tongyu Yang, Bin |
author_facet | Yang, Cheng Zhang, Chao Zhao, Zitong Zhu, Tongyu Yang, Bin |
author_sort | Yang, Cheng |
collection | PubMed |
description | The significant improvements in siRNA therapy have been achieved, which have great potential applications in humans. The kidney is a comparatively easy target organ of siRNA therapy due to its unique structural and functional characteristics. Here, we reviewed recent achievements in siRNA design, delivery and application with focuses on kidney diseases, in particular kidney transplant-related injuries. In addition, the strategy for increasing serum stability and immune tolerance of siRNA was also discussed. At last, the future challenges of siRNA therapy including organ/tissue/cell-specific delivery and time-controlled silence, as well as selecting therapeutic targets, were addressed as well. |
format | Online Article Text |
id | pubmed-4354745 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-43547452015-03-11 Fighting against kidney diseases with small interfering RNA: opportunities and challenges Yang, Cheng Zhang, Chao Zhao, Zitong Zhu, Tongyu Yang, Bin J Transl Med Review The significant improvements in siRNA therapy have been achieved, which have great potential applications in humans. The kidney is a comparatively easy target organ of siRNA therapy due to its unique structural and functional characteristics. Here, we reviewed recent achievements in siRNA design, delivery and application with focuses on kidney diseases, in particular kidney transplant-related injuries. In addition, the strategy for increasing serum stability and immune tolerance of siRNA was also discussed. At last, the future challenges of siRNA therapy including organ/tissue/cell-specific delivery and time-controlled silence, as well as selecting therapeutic targets, were addressed as well. BioMed Central 2015-02-01 /pmc/articles/PMC4354745/ /pubmed/25637948 http://dx.doi.org/10.1186/s12967-015-0387-2 Text en © Yang et al.; licensee BioMed Central. 2015 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
spellingShingle | Review Yang, Cheng Zhang, Chao Zhao, Zitong Zhu, Tongyu Yang, Bin Fighting against kidney diseases with small interfering RNA: opportunities and challenges |
title | Fighting against kidney diseases with small interfering RNA: opportunities and challenges |
title_full | Fighting against kidney diseases with small interfering RNA: opportunities and challenges |
title_fullStr | Fighting against kidney diseases with small interfering RNA: opportunities and challenges |
title_full_unstemmed | Fighting against kidney diseases with small interfering RNA: opportunities and challenges |
title_short | Fighting against kidney diseases with small interfering RNA: opportunities and challenges |
title_sort | fighting against kidney diseases with small interfering rna: opportunities and challenges |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4354745/ https://www.ncbi.nlm.nih.gov/pubmed/25637948 http://dx.doi.org/10.1186/s12967-015-0387-2 |
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