Cargando…

Inhibition of Bcl-2 Sensitizes Mitochondrial Permeability Transition Pore (MPTP) Opening in Ischemia-Damaged Mitochondria

BACKGROUND: Mitochondria are critical to cardiac injury during reperfusion as a result of damage sustained during ischemia, including the loss of bcl-2. We asked if bcl-2 depletion not only leads to selective permeation of the outer mitochondrial membrane (MOMP) favoring cytochrome c release and pro...

Descripción completa

Detalles Bibliográficos
Autores principales:	Chen, Qun, Xu, Haishan, Xu, Aijun, Ross, Thomas, Bowler, Elizabeth, Hu, Ying, Lesnefsky, Edward J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2015
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4354902/ https://www.ncbi.nlm.nih.gov/pubmed/25756500 http://dx.doi.org/10.1371/journal.pone.0118834

Ejemplares similares

Calcium Elevation in Mitochondria Is the Main Ca(2+) Requirement for Mitochondrial Permeability Transition Pore (mPTP) Opening
por: Baumgartner, Heidi K., et al.
Publicado: (2009)

Discovery of a new mitochondria permeability transition pore (mPTP) inhibitor based on gallic acid
por: Teixeira, José, et al.
Publicado: (2018)

Astaxanthin Inhibits Mitochondrial Permeability Transition Pore Opening in Rat Heart Mitochondria
por: Baburina, Yulia, et al.
Publicado: (2019)

Regulation of Mitochondrial Permeability Transition Pore Opening by Monovalent Cations in Liver Mitochondria
por: Kharechkina, Ekaterina S., et al.
Publicado: (2023)

Cellular calcification induced by inorganic polyphosphate involves ATP depletion and opening of the mitochondrial permeability transition pore (mPTP)
por: Tsutsumi, Kaori, et al.
Publicado: (2019)

Aging Enhances the Activation of the Permeability Transition Pore in Mitochondria
por: Rottenberg, Hagai, et al.
Publicado: (2001)

Schisandrin B Antagonizes Cardiotoxicity Induced by Pirarubicin by Inhibiting Mitochondrial Permeability Transition Pore (mPTP) Opening and Decreasing Cardiomyocyte Apoptosis
por: Shi, Hongwei, et al.
Publicado: (2021)

Corrigendum: Schisandrin B Antagonizes Cardiotoxicity Induced by Pirarubicin by Inhibiting Mitochondrial Permeability Transition Pore (mPTP) Opening and Decreasing Cardiomyocyte Apoptosis
por: Shi, Hongwei, et al.
Publicado: (2021)

Mitochondrial permeability transition pore induces mitochondria injury in Huntington disease
por: Quintanilla, Rodrigo A, et al.
Publicado: (2013)

The calcium uniporter regulates the permeability transition pore in isolated cortical mitochondria★
por: Yu, Ning, et al.
Publicado: (2012)

Erastin Disrupts Mitochondrial Permeability Transition Pore (mPTP) and Induces Apoptotic Death of Colorectal Cancer Cells
por: Huo, Haizhong, et al.
Publicado: (2016)

Curculigoside attenuates myocardial ischemia-reperfusion injury by inhibiting the opening of the mitochondrial permeability transition pore
por: Zhao, Yanbing, et al.
Publicado: (2020)

Dual dynamics of mitochondrial permeability transition pore opening
por: Wacquier, Benjamin, et al.
Publicado: (2020)

The Obesity-Related Peptide Leptin Sensitizes Cardiac Mitochondria to Calcium-Induced Permeability Transition Pore Opening and Apoptosis
por: Martinez-Abundis, Eduardo, et al.
Publicado: (2012)

NAD(H) Regulates the Permeability Transition Pore in Mitochondria through an External Site
por: Kharechkina, Ekaterina, et al.
Publicado: (2021)

Inhibition of permeability transition pore opening by mitochondrial STAT3 and its role in myocardial ischemia/reperfusion
por: Boengler, Kerstin, et al.
Publicado: (2010)

Hydroxytyrosol protects against myocardial ischemia reperfusion injury by inhibiting mitochondrial permeability transition pore opening
por: Miao, Jiaxin, et al.
Publicado: (2019)

Lycopene protects against myocardial ischemia-reperfusion injury by inhibiting mitochondrial permeability transition pore opening
por: Li, Xuying, et al.
Publicado: (2019)

Mitochondrial Dysfunction and Alterations in Mitochondrial Permeability Transition Pore (mPTP) Contribute to Apoptosis Resistance in Idiopathic Pulmonary Fibrosis Fibroblasts
por: Luis-García, Erika Rubí, et al.
Publicado: (2021)

Isoproterenol-Induced Permeability Transition Pore-Related Dysfunction of Heart Mitochondria Is Attenuated by Astaxanthin
por: Krestinin, Roman, et al.
Publicado: (2020)

The Permeability Transition Pore Complex: A Target for Apoptosis Regulation by Caspases and Bcl-2–related Proteins
por: Marzo, Isabel, et al.
Publicado: (1998)

Calpain-mediated protein targets in cardiac mitochondria following ischemia–reperfusion
por: Li, Ling, et al.
Publicado: (2022)

Tunicamycin-Induced Endoplasmic Reticulum Stress Damages Complex I in Cardiac Mitochondria
por: Chen, Qun, et al.
Publicado: (2022)

ROS‐Mediated PARP Activity Undermines Mitochondrial Function After Permeability Transition Pore Opening During Myocardial Ischemia–Reperfusion
por: Schriewer, Jacqueline M., et al.
Publicado: (2013)

Phosphorylation of cyclophilin D at serine 191 regulates mitochondrial permeability transition pore opening and cell death after ischemia-reperfusion
por: Hurst, Stephen, et al.
Publicado: (2020)

Mitochondrial permeability transition pore: sensitivity to opening and mechanistic dependence on substrate availability
por: Briston, Thomas, et al.
Publicado: (2017)

Targeting the Mitochondrial Permeability Transition Pore to Prevent Age-Associated Cell Damage and Neurodegeneration
por: Kent, Andrew C., et al.
Publicado: (2021)

Ischemia and reperfusion injury to mitochondria and cardiac function in donation after circulatory death hearts- an experimental study
por: Akande, Oluwatoyin, et al.
Publicado: (2020)

Mitochondrial Depolarization During TNF-induced Apoptosis is Caspase-dependent and Independent of Bcl-x L and the Permeability Transition Pore
por: Cepero, E., et al.
Publicado: (2001)

Carbenoxolon Is Capable to Regulate the Mitochondrial Permeability Transition Pore Opening in Chronic Alcohol Intoxication
por: Baburina, Yulia, et al.
Publicado: (2021)

Protocols for analysis of mitochondrial permeability transition pore opening in mouse somatic cell reprogramming
por: Ying, Zhongfu, et al.
Publicado: (2021)

Data supporting the involvement of the adenine nucleotide translocase conformation in opening the Tl(+)-induced permeability transition pore in Ca(2+)-loaded rat liver mitochondria
por: Korotkov, Sergey M.
Publicado: (2016)

The Effects of PK11195 and Protoporphyrin IX Can Modulate Chronic Alcohol Intoxication in Rat Liver Mitochondria under the Opening of the Mitochondrial Permeability Transition Pore
por: Baburina, Yulia, et al.
Publicado: (2020)

Effect of the CRAC Peptide, VLNYYVW, on mPTP Opening in Rat Brain and Liver Mitochondria
por: Azarashvili, Tamara, et al.
Publicado: (2016)

Identification of Phosphorylated Calpain 3 in Rat Brain Mitochondria under mPTP Opening
por: Baburuna, Yulia, et al.
Publicado: (2021)

Nanoparticle-Mediated Targeting of Cyclosporine A Enhances Cardioprotection Against Ischemia-Reperfusion Injury Through Inhibition of Mitochondrial Permeability Transition Pore Opening
por: Ikeda, Gentaro, et al.
Publicado: (2016)

Hexokinase II dissociation alone cannot account for changes in heart mitochondrial function, morphology and sensitivity to permeability transition pore opening following ischemia
por: Pereira, Gonçalo C., et al.
Publicado: (2020)

α-synuclein oligomers interact with ATP synthase and open the permeability transition pore in Parkinson’s disease
por: Ludtmann, Marthe H. R., et al.
Publicado: (2018)

Regulation of mitochondrial permeability transition pore by PINK1
por: Giaime, Emilie, et al.
Publicado: (2012)

The mitochondrial permeability transition pore: a mystery solved?
por: Bernardi, Paolo
Publicado: (2013)

Cannot write session to /tmp/vufind_sessions/sess_5hjkkq2as51vprmov2jsrn977s