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Chronic hyperglycemia downregulates GLP-1 receptor signaling in pancreatic β-cells via protein kinase A

OBJECTIVE: Glucagon-like peptide 1 (GLP-1) enhances insulin secretion and protects β-cell mass. Diabetes therapies targeting the GLP-1 receptor (GLP-1R), expressed in numerous tissues, have diminished dose-response in patients with type 2 diabetes compared with healthy human controls. The aim of thi...

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Detalles Bibliográficos
Autores principales:	Rajan, Sindhu, Dickson, Lorna M., Mathew, Elizabeth, Orr, Caitlin M.O., Ellenbroek, Johanne H., Philipson, Louis H., Wicksteed, Barton
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2015
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4354925/ https://www.ncbi.nlm.nih.gov/pubmed/25830090 http://dx.doi.org/10.1016/j.molmet.2015.01.010

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