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Serum progranulin levels are elevated in dermatomyositis patients with acute interstitial lung disease, predicting prognosis
INTRODUCTION: Progranulin (PGRN), a pleiotropic growth factor, has emerged as an immunoregulatory molecule. Because the roles of PGRN in dermatomyositis (DM) are still unknown, we investigated whether serum PGRN levels are associated with disease activity and prognosis in DM patients, particularly i...
Autores principales: | , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4354987/ https://www.ncbi.nlm.nih.gov/pubmed/25888887 http://dx.doi.org/10.1186/s13075-015-0547-z |
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author | Tanaka, Atsushi Tsukamoto, Hiroshi Mitoma, Hiroki Kiyohara, Chikako Ueda, Naoyasu Ayano, Masahiro Ohta, Shun-ichiro Kimoto, Yasutaka Akahoshi, Mitsuteru Arinobu, Yojiro Niiro, Hiroaki Tada, Yoshifumi Horiuchi, Takahiko Akashi, Koichi |
author_facet | Tanaka, Atsushi Tsukamoto, Hiroshi Mitoma, Hiroki Kiyohara, Chikako Ueda, Naoyasu Ayano, Masahiro Ohta, Shun-ichiro Kimoto, Yasutaka Akahoshi, Mitsuteru Arinobu, Yojiro Niiro, Hiroaki Tada, Yoshifumi Horiuchi, Takahiko Akashi, Koichi |
author_sort | Tanaka, Atsushi |
collection | PubMed |
description | INTRODUCTION: Progranulin (PGRN), a pleiotropic growth factor, has emerged as an immunoregulatory molecule. Because the roles of PGRN in dermatomyositis (DM) are still unknown, we investigated whether serum PGRN levels are associated with disease activity and prognosis in DM patients, particularly in those with DM complicated with interstitial lung disease (ILD). METHODS: The serum levels of PGRN were measured by enzyme-linked immunosorbent assay in patients with DM (n =57; acute/subacute interstitial pneumonia (A/SIP): n =17, chronic interstitial pneumonia (CIP): n =24, without ILD: n =16), polymyositis (PM, n =21; including 6 with ILD) and normal healthy controls (NHCs, n =60). We assessed the correlation between the serum PGRN levels and the activity indexes of ILD or prognosis in DM patients with ILD. RESULTS: Serum PGRN levels were significantly higher in DM patients than in PM patients (P =0.0025) and in NHCs (P <0.0001). In DM patients, the levels were significantly higher in patients with A/SIP than in those with CIP (P <0.0001) or without ILD (P =0.0003). The serum PGRN levels in DM patients with ILD significantly correlated with serum ferritin (r(S) =0.77, P <0.0001), lactate dehydrogenase (r(S) =0.54, P =0.0003) and C-reactive protein (r(S) =0.48, P =0.0015) levels. Moreover, in DM patients with ILD, the cumulative survival rate for 6 months was significantly lower in the group with serum PGRN levels ≥200 ng/ml (67%) than in the group with serum PGRN levels <200 ng/ml (100%) (P =0.0009). CONCLUSIONS: Serum PGRN is associated with disease activity and prognosis of DM with ILD. PGRN may play a role in the pathogenesis of DM and could be a useful biomarker. |
format | Online Article Text |
id | pubmed-4354987 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-43549872015-03-12 Serum progranulin levels are elevated in dermatomyositis patients with acute interstitial lung disease, predicting prognosis Tanaka, Atsushi Tsukamoto, Hiroshi Mitoma, Hiroki Kiyohara, Chikako Ueda, Naoyasu Ayano, Masahiro Ohta, Shun-ichiro Kimoto, Yasutaka Akahoshi, Mitsuteru Arinobu, Yojiro Niiro, Hiroaki Tada, Yoshifumi Horiuchi, Takahiko Akashi, Koichi Arthritis Res Ther Research Article INTRODUCTION: Progranulin (PGRN), a pleiotropic growth factor, has emerged as an immunoregulatory molecule. Because the roles of PGRN in dermatomyositis (DM) are still unknown, we investigated whether serum PGRN levels are associated with disease activity and prognosis in DM patients, particularly in those with DM complicated with interstitial lung disease (ILD). METHODS: The serum levels of PGRN were measured by enzyme-linked immunosorbent assay in patients with DM (n =57; acute/subacute interstitial pneumonia (A/SIP): n =17, chronic interstitial pneumonia (CIP): n =24, without ILD: n =16), polymyositis (PM, n =21; including 6 with ILD) and normal healthy controls (NHCs, n =60). We assessed the correlation between the serum PGRN levels and the activity indexes of ILD or prognosis in DM patients with ILD. RESULTS: Serum PGRN levels were significantly higher in DM patients than in PM patients (P =0.0025) and in NHCs (P <0.0001). In DM patients, the levels were significantly higher in patients with A/SIP than in those with CIP (P <0.0001) or without ILD (P =0.0003). The serum PGRN levels in DM patients with ILD significantly correlated with serum ferritin (r(S) =0.77, P <0.0001), lactate dehydrogenase (r(S) =0.54, P =0.0003) and C-reactive protein (r(S) =0.48, P =0.0015) levels. Moreover, in DM patients with ILD, the cumulative survival rate for 6 months was significantly lower in the group with serum PGRN levels ≥200 ng/ml (67%) than in the group with serum PGRN levels <200 ng/ml (100%) (P =0.0009). CONCLUSIONS: Serum PGRN is associated with disease activity and prognosis of DM with ILD. PGRN may play a role in the pathogenesis of DM and could be a useful biomarker. BioMed Central 2015-02-10 2015 /pmc/articles/PMC4354987/ /pubmed/25888887 http://dx.doi.org/10.1186/s13075-015-0547-z Text en © Tanaka et al.; licensee BioMed Central. 2015 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
spellingShingle | Research Article Tanaka, Atsushi Tsukamoto, Hiroshi Mitoma, Hiroki Kiyohara, Chikako Ueda, Naoyasu Ayano, Masahiro Ohta, Shun-ichiro Kimoto, Yasutaka Akahoshi, Mitsuteru Arinobu, Yojiro Niiro, Hiroaki Tada, Yoshifumi Horiuchi, Takahiko Akashi, Koichi Serum progranulin levels are elevated in dermatomyositis patients with acute interstitial lung disease, predicting prognosis |
title | Serum progranulin levels are elevated in dermatomyositis patients with acute interstitial lung disease, predicting prognosis |
title_full | Serum progranulin levels are elevated in dermatomyositis patients with acute interstitial lung disease, predicting prognosis |
title_fullStr | Serum progranulin levels are elevated in dermatomyositis patients with acute interstitial lung disease, predicting prognosis |
title_full_unstemmed | Serum progranulin levels are elevated in dermatomyositis patients with acute interstitial lung disease, predicting prognosis |
title_short | Serum progranulin levels are elevated in dermatomyositis patients with acute interstitial lung disease, predicting prognosis |
title_sort | serum progranulin levels are elevated in dermatomyositis patients with acute interstitial lung disease, predicting prognosis |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4354987/ https://www.ncbi.nlm.nih.gov/pubmed/25888887 http://dx.doi.org/10.1186/s13075-015-0547-z |
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