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Serum progranulin levels are elevated in dermatomyositis patients with acute interstitial lung disease, predicting prognosis

INTRODUCTION: Progranulin (PGRN), a pleiotropic growth factor, has emerged as an immunoregulatory molecule. Because the roles of PGRN in dermatomyositis (DM) are still unknown, we investigated whether serum PGRN levels are associated with disease activity and prognosis in DM patients, particularly i...

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Autores principales: Tanaka, Atsushi, Tsukamoto, Hiroshi, Mitoma, Hiroki, Kiyohara, Chikako, Ueda, Naoyasu, Ayano, Masahiro, Ohta, Shun-ichiro, Kimoto, Yasutaka, Akahoshi, Mitsuteru, Arinobu, Yojiro, Niiro, Hiroaki, Tada, Yoshifumi, Horiuchi, Takahiko, Akashi, Koichi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4354987/
https://www.ncbi.nlm.nih.gov/pubmed/25888887
http://dx.doi.org/10.1186/s13075-015-0547-z
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author Tanaka, Atsushi
Tsukamoto, Hiroshi
Mitoma, Hiroki
Kiyohara, Chikako
Ueda, Naoyasu
Ayano, Masahiro
Ohta, Shun-ichiro
Kimoto, Yasutaka
Akahoshi, Mitsuteru
Arinobu, Yojiro
Niiro, Hiroaki
Tada, Yoshifumi
Horiuchi, Takahiko
Akashi, Koichi
author_facet Tanaka, Atsushi
Tsukamoto, Hiroshi
Mitoma, Hiroki
Kiyohara, Chikako
Ueda, Naoyasu
Ayano, Masahiro
Ohta, Shun-ichiro
Kimoto, Yasutaka
Akahoshi, Mitsuteru
Arinobu, Yojiro
Niiro, Hiroaki
Tada, Yoshifumi
Horiuchi, Takahiko
Akashi, Koichi
author_sort Tanaka, Atsushi
collection PubMed
description INTRODUCTION: Progranulin (PGRN), a pleiotropic growth factor, has emerged as an immunoregulatory molecule. Because the roles of PGRN in dermatomyositis (DM) are still unknown, we investigated whether serum PGRN levels are associated with disease activity and prognosis in DM patients, particularly in those with DM complicated with interstitial lung disease (ILD). METHODS: The serum levels of PGRN were measured by enzyme-linked immunosorbent assay in patients with DM (n =57; acute/subacute interstitial pneumonia (A/SIP): n =17, chronic interstitial pneumonia (CIP): n =24, without ILD: n =16), polymyositis (PM, n =21; including 6 with ILD) and normal healthy controls (NHCs, n =60). We assessed the correlation between the serum PGRN levels and the activity indexes of ILD or prognosis in DM patients with ILD. RESULTS: Serum PGRN levels were significantly higher in DM patients than in PM patients (P =0.0025) and in NHCs (P <0.0001). In DM patients, the levels were significantly higher in patients with A/SIP than in those with CIP (P <0.0001) or without ILD (P =0.0003). The serum PGRN levels in DM patients with ILD significantly correlated with serum ferritin (r(S) =0.77, P <0.0001), lactate dehydrogenase (r(S) =0.54, P =0.0003) and C-reactive protein (r(S) =0.48, P =0.0015) levels. Moreover, in DM patients with ILD, the cumulative survival rate for 6 months was significantly lower in the group with serum PGRN levels ≥200 ng/ml (67%) than in the group with serum PGRN levels <200 ng/ml (100%) (P =0.0009). CONCLUSIONS: Serum PGRN is associated with disease activity and prognosis of DM with ILD. PGRN may play a role in the pathogenesis of DM and could be a useful biomarker.
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spelling pubmed-43549872015-03-12 Serum progranulin levels are elevated in dermatomyositis patients with acute interstitial lung disease, predicting prognosis Tanaka, Atsushi Tsukamoto, Hiroshi Mitoma, Hiroki Kiyohara, Chikako Ueda, Naoyasu Ayano, Masahiro Ohta, Shun-ichiro Kimoto, Yasutaka Akahoshi, Mitsuteru Arinobu, Yojiro Niiro, Hiroaki Tada, Yoshifumi Horiuchi, Takahiko Akashi, Koichi Arthritis Res Ther Research Article INTRODUCTION: Progranulin (PGRN), a pleiotropic growth factor, has emerged as an immunoregulatory molecule. Because the roles of PGRN in dermatomyositis (DM) are still unknown, we investigated whether serum PGRN levels are associated with disease activity and prognosis in DM patients, particularly in those with DM complicated with interstitial lung disease (ILD). METHODS: The serum levels of PGRN were measured by enzyme-linked immunosorbent assay in patients with DM (n =57; acute/subacute interstitial pneumonia (A/SIP): n =17, chronic interstitial pneumonia (CIP): n =24, without ILD: n =16), polymyositis (PM, n =21; including 6 with ILD) and normal healthy controls (NHCs, n =60). We assessed the correlation between the serum PGRN levels and the activity indexes of ILD or prognosis in DM patients with ILD. RESULTS: Serum PGRN levels were significantly higher in DM patients than in PM patients (P =0.0025) and in NHCs (P <0.0001). In DM patients, the levels were significantly higher in patients with A/SIP than in those with CIP (P <0.0001) or without ILD (P =0.0003). The serum PGRN levels in DM patients with ILD significantly correlated with serum ferritin (r(S) =0.77, P <0.0001), lactate dehydrogenase (r(S) =0.54, P =0.0003) and C-reactive protein (r(S) =0.48, P =0.0015) levels. Moreover, in DM patients with ILD, the cumulative survival rate for 6 months was significantly lower in the group with serum PGRN levels ≥200 ng/ml (67%) than in the group with serum PGRN levels <200 ng/ml (100%) (P =0.0009). CONCLUSIONS: Serum PGRN is associated with disease activity and prognosis of DM with ILD. PGRN may play a role in the pathogenesis of DM and could be a useful biomarker. BioMed Central 2015-02-10 2015 /pmc/articles/PMC4354987/ /pubmed/25888887 http://dx.doi.org/10.1186/s13075-015-0547-z Text en © Tanaka et al.; licensee BioMed Central. 2015 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research Article
Tanaka, Atsushi
Tsukamoto, Hiroshi
Mitoma, Hiroki
Kiyohara, Chikako
Ueda, Naoyasu
Ayano, Masahiro
Ohta, Shun-ichiro
Kimoto, Yasutaka
Akahoshi, Mitsuteru
Arinobu, Yojiro
Niiro, Hiroaki
Tada, Yoshifumi
Horiuchi, Takahiko
Akashi, Koichi
Serum progranulin levels are elevated in dermatomyositis patients with acute interstitial lung disease, predicting prognosis
title Serum progranulin levels are elevated in dermatomyositis patients with acute interstitial lung disease, predicting prognosis
title_full Serum progranulin levels are elevated in dermatomyositis patients with acute interstitial lung disease, predicting prognosis
title_fullStr Serum progranulin levels are elevated in dermatomyositis patients with acute interstitial lung disease, predicting prognosis
title_full_unstemmed Serum progranulin levels are elevated in dermatomyositis patients with acute interstitial lung disease, predicting prognosis
title_short Serum progranulin levels are elevated in dermatomyositis patients with acute interstitial lung disease, predicting prognosis
title_sort serum progranulin levels are elevated in dermatomyositis patients with acute interstitial lung disease, predicting prognosis
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4354987/
https://www.ncbi.nlm.nih.gov/pubmed/25888887
http://dx.doi.org/10.1186/s13075-015-0547-z
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