Cargando…
Volume reduction of benign thyroid nodules 3 months after a single treatment with high-intensity focused ultrasound (HIFU)
BACKGROUND: High-intensity focused ultrasound (HIFU) is a promising, non-invasive technique in treating benign thyroid nodules (TNs). The aim of this study was to evaluate the efficacy of HIFU to induce clinically meaningful shrinkage in benign predominantly solid TNs and to identify variables that...
Autores principales: | , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2015
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4355001/ https://www.ncbi.nlm.nih.gov/pubmed/25763185 http://dx.doi.org/10.1186/s40349-015-0024-9 |
_version_ | 1782360814309605376 |
---|---|
author | Korkusuz, Huedayi Fehre, Niklas Sennert, Michael Happel, Christian Grünwald, Frank |
author_facet | Korkusuz, Huedayi Fehre, Niklas Sennert, Michael Happel, Christian Grünwald, Frank |
author_sort | Korkusuz, Huedayi |
collection | PubMed |
description | BACKGROUND: High-intensity focused ultrasound (HIFU) is a promising, non-invasive technique in treating benign thyroid nodules (TNs). The aim of this study was to evaluate the efficacy of HIFU to induce clinically meaningful shrinkage in benign predominantly solid TNs and to identify variables that influence or predict the magnitude of TN volume reduction. METHODS: For each of ten subjects, HIFU treatment was conducted on a single nodule. Nodular volume was measured sonographically at baseline and at 3 months post-procedure. Nodular function and early treatment assessment was done scintigraphically. RESULTS: Median nodular volume reduction was 0.7 ml absolute and 48.8% relative to pre-interventional size (p < 0.05). Absolute shrinkage was negatively correlated with the average treatment depth (τ = −0.61, p < 0.05). Absolute nodular volume was positively correlated with the scintigraphic nodular uptake reduction (τ = 0.66, p < 0.05). CONCLUSIONS: HIFU treatment of benign predominantly solid TNs appears to be safe and effective for inducing nodular shrinkage. Despite potential for improvement, a single treatment session with HIFU is already a viable alternative to more standard methods. The feasibility of multiple HIFU treatments requires further investigation. Due to the small sample size, the findings of this analysis need conformation by larger studies. |
format | Online Article Text |
id | pubmed-4355001 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-43550012015-03-12 Volume reduction of benign thyroid nodules 3 months after a single treatment with high-intensity focused ultrasound (HIFU) Korkusuz, Huedayi Fehre, Niklas Sennert, Michael Happel, Christian Grünwald, Frank J Ther Ultrasound Research BACKGROUND: High-intensity focused ultrasound (HIFU) is a promising, non-invasive technique in treating benign thyroid nodules (TNs). The aim of this study was to evaluate the efficacy of HIFU to induce clinically meaningful shrinkage in benign predominantly solid TNs and to identify variables that influence or predict the magnitude of TN volume reduction. METHODS: For each of ten subjects, HIFU treatment was conducted on a single nodule. Nodular volume was measured sonographically at baseline and at 3 months post-procedure. Nodular function and early treatment assessment was done scintigraphically. RESULTS: Median nodular volume reduction was 0.7 ml absolute and 48.8% relative to pre-interventional size (p < 0.05). Absolute shrinkage was negatively correlated with the average treatment depth (τ = −0.61, p < 0.05). Absolute nodular volume was positively correlated with the scintigraphic nodular uptake reduction (τ = 0.66, p < 0.05). CONCLUSIONS: HIFU treatment of benign predominantly solid TNs appears to be safe and effective for inducing nodular shrinkage. Despite potential for improvement, a single treatment session with HIFU is already a viable alternative to more standard methods. The feasibility of multiple HIFU treatments requires further investigation. Due to the small sample size, the findings of this analysis need conformation by larger studies. BioMed Central 2015-03-04 /pmc/articles/PMC4355001/ /pubmed/25763185 http://dx.doi.org/10.1186/s40349-015-0024-9 Text en © Korkusuz et al.; licensee BioMed Central. 2015 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
spellingShingle | Research Korkusuz, Huedayi Fehre, Niklas Sennert, Michael Happel, Christian Grünwald, Frank Volume reduction of benign thyroid nodules 3 months after a single treatment with high-intensity focused ultrasound (HIFU) |
title | Volume reduction of benign thyroid nodules 3 months after a single treatment with high-intensity focused ultrasound (HIFU) |
title_full | Volume reduction of benign thyroid nodules 3 months after a single treatment with high-intensity focused ultrasound (HIFU) |
title_fullStr | Volume reduction of benign thyroid nodules 3 months after a single treatment with high-intensity focused ultrasound (HIFU) |
title_full_unstemmed | Volume reduction of benign thyroid nodules 3 months after a single treatment with high-intensity focused ultrasound (HIFU) |
title_short | Volume reduction of benign thyroid nodules 3 months after a single treatment with high-intensity focused ultrasound (HIFU) |
title_sort | volume reduction of benign thyroid nodules 3 months after a single treatment with high-intensity focused ultrasound (hifu) |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4355001/ https://www.ncbi.nlm.nih.gov/pubmed/25763185 http://dx.doi.org/10.1186/s40349-015-0024-9 |
work_keys_str_mv | AT korkusuzhuedayi volumereductionofbenignthyroidnodules3monthsafterasingletreatmentwithhighintensityfocusedultrasoundhifu AT fehreniklas volumereductionofbenignthyroidnodules3monthsafterasingletreatmentwithhighintensityfocusedultrasoundhifu AT sennertmichael volumereductionofbenignthyroidnodules3monthsafterasingletreatmentwithhighintensityfocusedultrasoundhifu AT happelchristian volumereductionofbenignthyroidnodules3monthsafterasingletreatmentwithhighintensityfocusedultrasoundhifu AT grunwaldfrank volumereductionofbenignthyroidnodules3monthsafterasingletreatmentwithhighintensityfocusedultrasoundhifu |