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Evolution of Metabolic Abnormalities in Alcoholic Patients during Withdrawal
Chronic alcohol intoxication is accompanied by metabolic abnormalities. Evolution during the early withdrawal period has been poorly investigated. The aim of this study was to determine the evolution of metabolic parameters during alcohol withdrawal. Patients and Methods. Thirty-three patients admit...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4355116/ https://www.ncbi.nlm.nih.gov/pubmed/25810945 http://dx.doi.org/10.1155/2015/541536 |
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author | Vandemergel, X. Simon, F. |
author_facet | Vandemergel, X. Simon, F. |
author_sort | Vandemergel, X. |
collection | PubMed |
description | Chronic alcohol intoxication is accompanied by metabolic abnormalities. Evolution during the early withdrawal period has been poorly investigated. The aim of this study was to determine the evolution of metabolic parameters during alcohol withdrawal. Patients and Methods. Thirty-three patients admitted in our department for alcohol withdrawal were prospectively included. Results. Baseline hypophosphatemia was found in 24% of cases. FEPO4 was reduced from 14.2 ± 9% at baseline to 7.3 ± 4.2% at day 3 (P < 0.01). FEPO4 inversely correlated with albuminemia (rs = −0.41, P = 0.01). CPK level was 124 ± 104 IU/L in men and 145 ± 85 IU/L in women (nl < 308 and <192 IU/L, resp.), 7% and 28% of patients having a CPK level >nl, respectively. No correlation was found between the sodium and CPK levels (P = 0.75) nor between the CPK level and the amount of alcohol ingested (rs = 0.084, P = 0.097). Baseline urate level was elevated and returned to normal after three days. Baseline magnesium concentration was normal and stable over time. Conclusion. Chronic alcohol intoxication was accompanied by phosphaturia, rapidly reversible after alcohol withdrawal and inversely correlated with albuminemia, slight hyponatremia, low levels of 25 hydroxy vitamin D, elevated CPK level in about 30% of women, and hyperuricemia with rapid normalization. |
format | Online Article Text |
id | pubmed-4355116 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-43551162015-03-25 Evolution of Metabolic Abnormalities in Alcoholic Patients during Withdrawal Vandemergel, X. Simon, F. J Addict Research Article Chronic alcohol intoxication is accompanied by metabolic abnormalities. Evolution during the early withdrawal period has been poorly investigated. The aim of this study was to determine the evolution of metabolic parameters during alcohol withdrawal. Patients and Methods. Thirty-three patients admitted in our department for alcohol withdrawal were prospectively included. Results. Baseline hypophosphatemia was found in 24% of cases. FEPO4 was reduced from 14.2 ± 9% at baseline to 7.3 ± 4.2% at day 3 (P < 0.01). FEPO4 inversely correlated with albuminemia (rs = −0.41, P = 0.01). CPK level was 124 ± 104 IU/L in men and 145 ± 85 IU/L in women (nl < 308 and <192 IU/L, resp.), 7% and 28% of patients having a CPK level >nl, respectively. No correlation was found between the sodium and CPK levels (P = 0.75) nor between the CPK level and the amount of alcohol ingested (rs = 0.084, P = 0.097). Baseline urate level was elevated and returned to normal after three days. Baseline magnesium concentration was normal and stable over time. Conclusion. Chronic alcohol intoxication was accompanied by phosphaturia, rapidly reversible after alcohol withdrawal and inversely correlated with albuminemia, slight hyponatremia, low levels of 25 hydroxy vitamin D, elevated CPK level in about 30% of women, and hyperuricemia with rapid normalization. Hindawi Publishing Corporation 2015 2015-02-24 /pmc/articles/PMC4355116/ /pubmed/25810945 http://dx.doi.org/10.1155/2015/541536 Text en Copyright © 2015 X. Vandemergel and F. Simon. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Vandemergel, X. Simon, F. Evolution of Metabolic Abnormalities in Alcoholic Patients during Withdrawal |
title | Evolution of Metabolic Abnormalities in Alcoholic Patients during Withdrawal |
title_full | Evolution of Metabolic Abnormalities in Alcoholic Patients during Withdrawal |
title_fullStr | Evolution of Metabolic Abnormalities in Alcoholic Patients during Withdrawal |
title_full_unstemmed | Evolution of Metabolic Abnormalities in Alcoholic Patients during Withdrawal |
title_short | Evolution of Metabolic Abnormalities in Alcoholic Patients during Withdrawal |
title_sort | evolution of metabolic abnormalities in alcoholic patients during withdrawal |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4355116/ https://www.ncbi.nlm.nih.gov/pubmed/25810945 http://dx.doi.org/10.1155/2015/541536 |
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