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Protease 3C of hepatitis A virus induces vacuolization of lysosomal/endosomal organelles and caspase-independent cell death

BACKGROUND: 3C proteases, the main proteases of picornaviruses, play the key role in viral life cycle by processing polyproteins. In addition, 3C proteases digest certain host cell proteins to suppress antiviral defense, transcription, and translation. The activity of 3C proteases per se induces hos...

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Detalles Bibliográficos
Autores principales:	Shubin, Andrey V, Demidyuk, Ilya V, Lunina, Nataliya A, Komissarov, Alexey A, Roschina, Marina P, Leonova, Olga G, Kostrov, Sergey V
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2015
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4355371/ https://www.ncbi.nlm.nih.gov/pubmed/25886889 http://dx.doi.org/10.1186/s12860-015-0050-z

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