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The relationship between fasting plasma citrulline concentration and small intestinal function in the critically ill

INTRODUCTION: In this study, we aimed to evaluate whether fasting plasma citrulline concentration predicts subsequent glucose absorption in critically ill patients. METHODS: In a prospective observational study involving 15 healthy and 20 critically ill subjects, fasting plasma citrulline concentrat...

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Autores principales: Poole, Alexis, Deane, Adam, Summers, Matthew, Fletcher, Janice, Chapman, Marianne
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4355456/
https://www.ncbi.nlm.nih.gov/pubmed/25599966
http://dx.doi.org/10.1186/s13054-014-0725-4
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author Poole, Alexis
Deane, Adam
Summers, Matthew
Fletcher, Janice
Chapman, Marianne
author_facet Poole, Alexis
Deane, Adam
Summers, Matthew
Fletcher, Janice
Chapman, Marianne
author_sort Poole, Alexis
collection PubMed
description INTRODUCTION: In this study, we aimed to evaluate whether fasting plasma citrulline concentration predicts subsequent glucose absorption in critically ill patients. METHODS: In a prospective observational study involving 15 healthy and 20 critically ill subjects, fasting plasma citrulline concentrations were assayed in blood samples immediately prior to the administration of a liquid test meal (1 kcal/ml; containing 3 g of 3-O-methylglucose (3-OMG)) that was infused directly into the small intestine. Serum 3-OMG concentrations were measured over the following 4 hours, with the area under the 3-OMG concentration curve (AUC) calculated as an index of glucose absorption. RESULTS: The groups were well matched in terms of age, sex and body mass index (BMI) (healthy subjects versus patients, mean (range) values: age, 47 (18 to 88) versus 49 (21 to 77) years; sex ratio, 60% versus 80% male; BMI, 25.2 (18.8 to 30.0) versus 25.5 (19.4 to 32.2) kg/m(2)). Compared to the healthy subjects, patients who were critically ill had reduced fasting citrulline concentration (26.5 (13.9 to 43.0) versus 15.2 (5.7 to 28.6) μmol/L; P < 0.01) and glucose absorption (3-OMG AUC, 79.7 (28.6 to 117.8) versus 61.0 (4.5 to 97.1) mmol/L/240 min; P = 0.05). There was no relationship between fasting citrulline concentration and subsequent glucose absorption (r = 0.28; P = 0.12). CONCLUSIONS: Whereas both plasma citrulline concentrations and glucose absorption were reduced in critical illness, fasting plasma citrulline concentrations were not predictive of subsequent glucose absorption. These data suggest that fasting citrulline concentration does not appear to be a marker of small intestinal absorptive function in patients who are critically ill.
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spelling pubmed-43554562015-03-12 The relationship between fasting plasma citrulline concentration and small intestinal function in the critically ill Poole, Alexis Deane, Adam Summers, Matthew Fletcher, Janice Chapman, Marianne Crit Care Research INTRODUCTION: In this study, we aimed to evaluate whether fasting plasma citrulline concentration predicts subsequent glucose absorption in critically ill patients. METHODS: In a prospective observational study involving 15 healthy and 20 critically ill subjects, fasting plasma citrulline concentrations were assayed in blood samples immediately prior to the administration of a liquid test meal (1 kcal/ml; containing 3 g of 3-O-methylglucose (3-OMG)) that was infused directly into the small intestine. Serum 3-OMG concentrations were measured over the following 4 hours, with the area under the 3-OMG concentration curve (AUC) calculated as an index of glucose absorption. RESULTS: The groups were well matched in terms of age, sex and body mass index (BMI) (healthy subjects versus patients, mean (range) values: age, 47 (18 to 88) versus 49 (21 to 77) years; sex ratio, 60% versus 80% male; BMI, 25.2 (18.8 to 30.0) versus 25.5 (19.4 to 32.2) kg/m(2)). Compared to the healthy subjects, patients who were critically ill had reduced fasting citrulline concentration (26.5 (13.9 to 43.0) versus 15.2 (5.7 to 28.6) μmol/L; P < 0.01) and glucose absorption (3-OMG AUC, 79.7 (28.6 to 117.8) versus 61.0 (4.5 to 97.1) mmol/L/240 min; P = 0.05). There was no relationship between fasting citrulline concentration and subsequent glucose absorption (r = 0.28; P = 0.12). CONCLUSIONS: Whereas both plasma citrulline concentrations and glucose absorption were reduced in critical illness, fasting plasma citrulline concentrations were not predictive of subsequent glucose absorption. These data suggest that fasting citrulline concentration does not appear to be a marker of small intestinal absorptive function in patients who are critically ill. BioMed Central 2015-01-20 2015 /pmc/articles/PMC4355456/ /pubmed/25599966 http://dx.doi.org/10.1186/s13054-014-0725-4 Text en © Poole et al.; licensee BioMed Central. 2015 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research
Poole, Alexis
Deane, Adam
Summers, Matthew
Fletcher, Janice
Chapman, Marianne
The relationship between fasting plasma citrulline concentration and small intestinal function in the critically ill
title The relationship between fasting plasma citrulline concentration and small intestinal function in the critically ill
title_full The relationship between fasting plasma citrulline concentration and small intestinal function in the critically ill
title_fullStr The relationship between fasting plasma citrulline concentration and small intestinal function in the critically ill
title_full_unstemmed The relationship between fasting plasma citrulline concentration and small intestinal function in the critically ill
title_short The relationship between fasting plasma citrulline concentration and small intestinal function in the critically ill
title_sort relationship between fasting plasma citrulline concentration and small intestinal function in the critically ill
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4355456/
https://www.ncbi.nlm.nih.gov/pubmed/25599966
http://dx.doi.org/10.1186/s13054-014-0725-4
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