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LINGO-1 promotes lysosomal degradation of amyloid-β protein precursor

Sequential proteolytic cleavages of amyloid-β protein precursor (AβPP) by β-secretase and γ-secretase generate amyloid β (Aβ) peptides, which are thought to contribute to Alzheimer's disease (AD). Much of this processing occurs in endosomes following endocytosis of AβPP from the plasma membrane...

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Detalles Bibliográficos
Autores principales:	de Laat, Rian, Meabon, James S., Wiley, Jesse C., Hudson, Mark P., Montine, Thomas J., Bothwell, Mark
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Co-Action Publishing 2015
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4355507/ https://www.ncbi.nlm.nih.gov/pubmed/25758563 http://dx.doi.org/10.3402/pba.v5.25796

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