Cargando…

Adherence to Methotrexate in Rheumatoid Arthritis: A Danish Nationwide Cohort Study

Objectives. To study adherence to methotrexate (MTX) and factors of importance thereof in patients with rheumatoid arthritis (RA). Methods. Patients with a hospital diagnosis of RA (ICD10 codes M05.X or M06.X) after January 1, 1997, and aged ≥18 years at the date of first diagnosis/contact, with at...

Descripción completa

Detalles Bibliográficos
Autores principales: Bliddal, Henning, Eriksen, Stine A., Christensen, Robin, Lorenzen, Tove, Hansen, Michael S., Østergaard, Mikkel, Dreyer, Lene, Luta, George, Vestergaard, Peter
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4355606/
https://www.ncbi.nlm.nih.gov/pubmed/25810923
http://dx.doi.org/10.1155/2015/915142
_version_ 1782360886352019456
author Bliddal, Henning
Eriksen, Stine A.
Christensen, Robin
Lorenzen, Tove
Hansen, Michael S.
Østergaard, Mikkel
Dreyer, Lene
Luta, George
Vestergaard, Peter
author_facet Bliddal, Henning
Eriksen, Stine A.
Christensen, Robin
Lorenzen, Tove
Hansen, Michael S.
Østergaard, Mikkel
Dreyer, Lene
Luta, George
Vestergaard, Peter
author_sort Bliddal, Henning
collection PubMed
description Objectives. To study adherence to methotrexate (MTX) and factors of importance thereof in patients with rheumatoid arthritis (RA). Methods. Patients with a hospital diagnosis of RA (ICD10 codes M05.X or M06.X) after January 1, 1997, and aged ≥18 years at the date of first diagnosis/contact, with at least one prescription of MTX (L04AX03), were included. Results. A total of 18,703 (47.6%) patients had ever used MTX among 39,286 with a diagnosis of RA; among the MTX users, 16,503 (88.2%) had filed more than one MTX prescription. The median time from diagnosis to first MTX prescription was 0.66 (IQR 0.26–1.80) years. In those who filed more than one MTX prescription, the mean adherence time for ≥7.5 mg MTX per week was 1,925 (IQR 467–3,056) days for patients treated in private practice versus 1,892 (IQR 452–3,316) days for patients treated in hospital. The main determinants of nonadherence were female gender, younger age, and time from diagnosis to initiation of MTX. Conclusions. Treatment at hospital or in private practice did not influence the adherence to MTX. Nonmodifiable factors of importance were gender and age, while adherence to MTX therapy decreased with time lapse between diagnosis and prescription.
format Online
Article
Text
id pubmed-4355606
institution National Center for Biotechnology Information
language English
publishDate 2015
publisher Hindawi Publishing Corporation
record_format MEDLINE/PubMed
spelling pubmed-43556062015-03-25 Adherence to Methotrexate in Rheumatoid Arthritis: A Danish Nationwide Cohort Study Bliddal, Henning Eriksen, Stine A. Christensen, Robin Lorenzen, Tove Hansen, Michael S. Østergaard, Mikkel Dreyer, Lene Luta, George Vestergaard, Peter Arthritis Research Article Objectives. To study adherence to methotrexate (MTX) and factors of importance thereof in patients with rheumatoid arthritis (RA). Methods. Patients with a hospital diagnosis of RA (ICD10 codes M05.X or M06.X) after January 1, 1997, and aged ≥18 years at the date of first diagnosis/contact, with at least one prescription of MTX (L04AX03), were included. Results. A total of 18,703 (47.6%) patients had ever used MTX among 39,286 with a diagnosis of RA; among the MTX users, 16,503 (88.2%) had filed more than one MTX prescription. The median time from diagnosis to first MTX prescription was 0.66 (IQR 0.26–1.80) years. In those who filed more than one MTX prescription, the mean adherence time for ≥7.5 mg MTX per week was 1,925 (IQR 467–3,056) days for patients treated in private practice versus 1,892 (IQR 452–3,316) days for patients treated in hospital. The main determinants of nonadherence were female gender, younger age, and time from diagnosis to initiation of MTX. Conclusions. Treatment at hospital or in private practice did not influence the adherence to MTX. Nonmodifiable factors of importance were gender and age, while adherence to MTX therapy decreased with time lapse between diagnosis and prescription. Hindawi Publishing Corporation 2015 2015-02-25 /pmc/articles/PMC4355606/ /pubmed/25810923 http://dx.doi.org/10.1155/2015/915142 Text en Copyright © 2015 Henning Bliddal et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Bliddal, Henning
Eriksen, Stine A.
Christensen, Robin
Lorenzen, Tove
Hansen, Michael S.
Østergaard, Mikkel
Dreyer, Lene
Luta, George
Vestergaard, Peter
Adherence to Methotrexate in Rheumatoid Arthritis: A Danish Nationwide Cohort Study
title Adherence to Methotrexate in Rheumatoid Arthritis: A Danish Nationwide Cohort Study
title_full Adherence to Methotrexate in Rheumatoid Arthritis: A Danish Nationwide Cohort Study
title_fullStr Adherence to Methotrexate in Rheumatoid Arthritis: A Danish Nationwide Cohort Study
title_full_unstemmed Adherence to Methotrexate in Rheumatoid Arthritis: A Danish Nationwide Cohort Study
title_short Adherence to Methotrexate in Rheumatoid Arthritis: A Danish Nationwide Cohort Study
title_sort adherence to methotrexate in rheumatoid arthritis: a danish nationwide cohort study
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4355606/
https://www.ncbi.nlm.nih.gov/pubmed/25810923
http://dx.doi.org/10.1155/2015/915142
work_keys_str_mv AT bliddalhenning adherencetomethotrexateinrheumatoidarthritisadanishnationwidecohortstudy
AT eriksenstinea adherencetomethotrexateinrheumatoidarthritisadanishnationwidecohortstudy
AT christensenrobin adherencetomethotrexateinrheumatoidarthritisadanishnationwidecohortstudy
AT lorenzentove adherencetomethotrexateinrheumatoidarthritisadanishnationwidecohortstudy
AT hansenmichaels adherencetomethotrexateinrheumatoidarthritisadanishnationwidecohortstudy
AT østergaardmikkel adherencetomethotrexateinrheumatoidarthritisadanishnationwidecohortstudy
AT dreyerlene adherencetomethotrexateinrheumatoidarthritisadanishnationwidecohortstudy
AT lutageorge adherencetomethotrexateinrheumatoidarthritisadanishnationwidecohortstudy
AT vestergaardpeter adherencetomethotrexateinrheumatoidarthritisadanishnationwidecohortstudy