Cargando…

Actin foci facilitate activation of the phospholipase C-γ in primary T lymphocytes via the WASP pathway

Wiscott Aldrich Syndrome protein (WASP) deficiency results in defects in calcium ion signaling, cytoskeletal regulation, gene transcription and overall T cell activation. The activation of WASP constitutes a key pathway for actin filament nucleation. Yet, when WASP function is eliminated there is ne...

Descripción completa

Detalles Bibliográficos
Autores principales:	Kumari, Sudha, Depoil, David, Martinelli, Roberta, Judokusumo, Edward, Carmona, Guillaume, Gertler, Frank B, Kam, Lance C, Carman, Christopher V, Burkhardt, Janis K, Irvine, Darrell J, Dustin, Michael L
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	eLife Sciences Publications, Ltd 2015
Materias:	Cell Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4355629/ https://www.ncbi.nlm.nih.gov/pubmed/25758716 http://dx.doi.org/10.7554/eLife.04953

Ejemplares similares

Cutting Edge: Synapse Propensity of Human Memory CD8 T Cells Confers Competitive Advantage over Naive Counterparts
por: Mayya, Viveka, et al.
Publicado: (2019)

Durable Interactions of T Cells with T Cell Receptor Stimuli in the Absence of a Stable Immunological Synapse
por: Mayya, Viveka, et al.
Publicado: (2018)

A WASp-binding type II phosphatidylinositol 4-kinase required for actin polymerization-driven endosome motility
por: Chang, Fanny S., et al.
Publicado: (2005)

How Wasp Regulates Actin Polymerization
por: Zigmond, Sally H.
Publicado: (2000)

Phospholipase C-γ2 and Vav cooperate within signaling microclusters to propagate B cell spreading in response to membrane-bound antigen
por: Weber, Michele, et al.
Publicado: (2008)

Phospholipase C-γ2 and Vav cooperate within signaling microclusters to propagate B cell spreading in response to membrane-bound antigen
por: Weber, Michele, et al.
Publicado: (2008)

Expression of Enzymatically Inactive Wasp Venom Phospholipase A1 in Pichia pastoris
por: Borodina, Irina, et al.
Publicado: (2011)

F-actin polymerization and retrograde flow drive sustained PLCγ1 signaling during T cell activation
por: Babich, Alexander, et al.
Publicado: (2012)

Multiple actin networks coordinate mechanotransduction at the immunological synapse
por: Blumenthal, Daniel, et al.
Publicado: (2020)

Actin-Dependent Propulsion of Endosomes and Lysosomes by Recruitment of N-Wasp(✪)
por: Taunton, Jack, et al.
Publicado: (2000)

Processive acceleration of actin barbed-end assembly by N-WASP
por: Khanduja, Nimisha, et al.
Publicado: (2014)

Restoration of Responsiveness of Phospholipase Cγ2-Deficient Platelets by Enforced Expression of Phospholipase Cγ1
por: Zheng, Yongwei, et al.
Publicado: (2015)

Foci of cyclin A2 interact with actin and RhoA in mitosis
por: Loukil, Abdelhalim, et al.
Publicado: (2016)

The Actin Cytoskeleton: A Mechanical Intermediate for Signal Integration at the Immunological Synapse
por: Roy, Nathan H., et al.
Publicado: (2018)

Dynamic cortical actin remodeling by ERM proteins controls BCR microcluster organization and integrity
por: Treanor, Bebhinn, et al.
Publicado: (2011)

WASP and SCAR are evolutionarily conserved in actin-filled pseudopod-based motility
por: Fritz-Laylin, Lillian K., et al.
Publicado: (2017)

Biochemical characterization of a phospholipase A(2) homologue from the venom of the social wasp Polybia occidentalis
por: Diniz-Sousa, Rafaela, et al.
Publicado: (2018)

A deep learning model (FociRad) for automated detection of γ-H2AX foci and radiation dose estimation
por: Wanotayan, Rujira, et al.
Publicado: (2022)

INDUCTION AND PROMOTION OF γ‐GLUTAMYLTRANSPEPTIDASE‐POSITIVE FOCI IN THE RAT LIVER BY METHYLGLYOXAL
por: Martelli, Antonietta, et al.
Publicado: (1988)

Not All T Cell Synapses Are Built the Same Way
por: Kumari, Sudha, et al.
Publicado: (2019)

Agile CD22 nanoclusters run rings around fenced BCR
por: Depoil, David, et al.
Publicado: (2016)

Effects of Intracellular Calcium and Actin Cytoskeleton on TCR Mobility Measured by Fluorescence Recovery
por: Dushek, Omer, et al.
Publicado: (2008)

F-actin flow drives affinity maturation and spatial organization of LFA-1 at the immunological synapse
por: Comrie, William A., et al.
Publicado: (2015)

Residual γH2AX foci as an indication of lethal DNA lesions
por: Banáth, Judit P, et al.
Publicado: (2010)

Unregulated actin polymerization by WASp causes defects of mitosis and cytokinesis in X-linked neutropenia
por: Moulding, Dale A., et al.
Publicado: (2007)

Investigation into Early Steps of Actin Recognition by the Intrinsically Disordered N-WASP Domain V
por: Chan-Yao-Chong, Maud, et al.
Publicado: (2019)

WASp triggers mechanosensitive actin patches to facilitate immune cell migration in dense tissues
por: Gaertner, Florian, et al.
Publicado: (2022)

Parkin-mediated ubiquitination regulates phospholipase C-γ1
por: Dehvari, Nodi, et al.
Publicado: (2009)

Calcium influx through CRAC channels controls actin organization and dynamics at the immune synapse
por: Hartzell, Catherine A, et al.
Publicado: (2016)

RhoD regulates cytoskeletal dynamics via the actin nucleation–promoting factor WASp homologue associated with actin Golgi membranes and microtubules
por: Gad, Annica K. B., et al.
Publicado: (2012)

Phospholipase Cγ1 Mediates Intima Formation Through Akt‐Notch1 Signaling Independent of the Phospholipase Activity
por: Jiang, Dongyang, et al.
Publicado: (2017)

γH2AX Foci Form Preferentially in Euchromatin after Ionising-Radiation
por: Cowell, Ian G., et al.
Publicado: (2007)

B cells extract antigens at Arp2/3-generated actin foci interspersed with linear filaments
por: Roper, Sophie I, et al.
Publicado: (2019)

Targeting the actin nucleation promoting factor WASp provides a therapeutic approach for hematopoietic malignancies
por: Biber, Guy, et al.
Publicado: (2021)

Calcium Release at Fertilization in Starfish Eggs Is Mediated by Phospholipase Cγ
por: Carroll, David J., et al.
Publicado: (1997)

Phospholipase Cγ1 is essential for T cell development, activation, and tolerance
por: Fu, Guoping, et al.
Publicado: (2010)

Phospholipase Cη2 Activation Redirects Vesicle Trafficking by Regulating F-actin
por: Yamaga, Masaki, et al.
Publicado: (2015)

Purification and characterization of the first γ-phospholipase inhibitor (γPLI) from Bothrops jararaca snake serum
por: Serino-Silva, Caroline, et al.
Publicado: (2018)

Foci of decay
por: Wells, William A.
Publicado: (2004)

Cytoskeletal tension actively sustains the migratory T‐cell synaptic contact
por: Kumari, Sudha, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_j1butbjnan8mffrustlo5djvil