The effect of tumor volume on radiotherapy outcome and correlation with other prognostic factors in patients with T2 supraglottic cancer

The retrospective chart review of 110 patients with T2 supraglottic cancer who underwent radiotherapy was performed to correlate tumor volume with other prognostic factors and to analyze its impact on treatment results. Patients with involved nodes, poor histopathological tumor differentiation, or h...

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Autores principales: Rutkowski, Tomasz W., Maciejewski, Bogusław, Kołosza, Zofia, Wygoda, Andrzej, Składowski, Krzysztof, Hejduk, Beata, Rutkowski, Roman
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Termedia Publishing House 2014
Materias:
Original Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4355652/
https://www.ncbi.nlm.nih.gov/pubmed/25784843
http://dx.doi.org/10.5114/wo.2014.44542
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author Rutkowski, Tomasz W.
Maciejewski, Bogusław
Kołosza, Zofia
Wygoda, Andrzej
Składowski, Krzysztof
Hejduk, Beata
Rutkowski, Roman
author_facet Rutkowski, Tomasz W.
Maciejewski, Bogusław
Kołosza, Zofia
Wygoda, Andrzej
Składowski, Krzysztof
Hejduk, Beata
Rutkowski, Roman
author_sort Rutkowski, Tomasz W.
collection PubMed
description The retrospective chart review of 110 patients with T2 supraglottic cancer who underwent radiotherapy was performed to correlate tumor volume with other prognostic factors and to analyze its impact on treatment results. Patients with involved nodes, poor histopathological tumor differentiation, or hemoglobin concentration ≤ 14.3 g/dl had significantly larger tumors. Patients with large tumors had significantly lower 5-year local control rate, overall survival rate and presented significantly higher risk of nodal involvement and the ratio of poor histopathological differentiation of the tumor. Tumor volume significantly impacts radiotherapy outcome and should be considered to optimize treatment strategy for patients with T2 supraglottic cancer.
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spelling pubmed-43556522015-03-17 The effect of tumor volume on radiotherapy outcome and correlation with other prognostic factors in patients with T2 supraglottic cancer Rutkowski, Tomasz W. Maciejewski, Bogusław Kołosza, Zofia Wygoda, Andrzej Składowski, Krzysztof Hejduk, Beata Rutkowski, Roman Contemp Oncol (Pozn) Original Paper The retrospective chart review of 110 patients with T2 supraglottic cancer who underwent radiotherapy was performed to correlate tumor volume with other prognostic factors and to analyze its impact on treatment results. Patients with involved nodes, poor histopathological tumor differentiation, or hemoglobin concentration ≤ 14.3 g/dl had significantly larger tumors. Patients with large tumors had significantly lower 5-year local control rate, overall survival rate and presented significantly higher risk of nodal involvement and the ratio of poor histopathological differentiation of the tumor. Tumor volume significantly impacts radiotherapy outcome and should be considered to optimize treatment strategy for patients with T2 supraglottic cancer. Termedia Publishing House 2014-12-31 2014 /pmc/articles/PMC4355652/ /pubmed/25784843 http://dx.doi.org/10.5114/wo.2014.44542 Text en Copyright © 2014 Termedia http://creativecommons.org/licenses/by-nc-nd/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-Noncommercial 3.0 Unported License, permitting all non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Paper
Rutkowski, Tomasz W.
Maciejewski, Bogusław
Kołosza, Zofia
Wygoda, Andrzej
Składowski, Krzysztof
Hejduk, Beata
Rutkowski, Roman
The effect of tumor volume on radiotherapy outcome and correlation with other prognostic factors in patients with T2 supraglottic cancer
title The effect of tumor volume on radiotherapy outcome and correlation with other prognostic factors in patients with T2 supraglottic cancer
title_full The effect of tumor volume on radiotherapy outcome and correlation with other prognostic factors in patients with T2 supraglottic cancer
title_fullStr The effect of tumor volume on radiotherapy outcome and correlation with other prognostic factors in patients with T2 supraglottic cancer
title_full_unstemmed The effect of tumor volume on radiotherapy outcome and correlation with other prognostic factors in patients with T2 supraglottic cancer
title_short The effect of tumor volume on radiotherapy outcome and correlation with other prognostic factors in patients with T2 supraglottic cancer
title_sort effect of tumor volume on radiotherapy outcome and correlation with other prognostic factors in patients with t2 supraglottic cancer
topic Original Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4355652/
https://www.ncbi.nlm.nih.gov/pubmed/25784843
http://dx.doi.org/10.5114/wo.2014.44542
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