PIK3R1 negatively regulates the epithelial-mesenchymal transition and stem-like phenotype of renal cancer cells through the AKT/GSK3β/CTNNB1 signaling pathway

The phosphoinositide 3-kinase (PI3K)/protein kinase B (AKT) pathway has been identified as an important pathway in renal cell carcinoma (RCC). We have reported a nonsense mutation in PIK3R1, which encodes the regulatory subunit of PI3K, in a metastatic RCC (mRCC), while the mutation was absent in th...

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Detalles Bibliográficos
Autores principales: Lin, Youcheng, Yang, Zhao, Xu, Abai, Dong, Pei, Huang, Yi, Liu, Huan, Li, Feida, Wang, Haifeng, Xu, Qian, Wang, Yongqiang, Sun, Da, Zou, Yong, Zou, Xiaowen, Wang, Yu, Zhang, Duo, Liu, Hongjie, Wu, Xun, Zhang, Meng, Fu, Yu, Cai, Zhiming, Liu, Chunxiao, Wu, Song
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4355729/
https://www.ncbi.nlm.nih.gov/pubmed/25757764
http://dx.doi.org/10.1038/srep08997

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