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Formulation and Evaluation of Mouth Disintegrating Tablets of Atenolol and Atorvastatin

In this study, mouth-disintegrating tablets of atenolol and atorvastatin combination were formulated using superdisintegrants to impart fast disintegration. Fifteen formulations were prepared based on different concentrations of two superdisintegrants, croscarmellose sodium and Kyron-T(134). Three d...

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Autores principales: Sarfraz, R. M., Khan, H. U., Mahmood, A., Ahmad, M., Maheen, S., Sher, M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4355887/
https://www.ncbi.nlm.nih.gov/pubmed/25767322
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author Sarfraz, R. M.
Khan, H. U.
Mahmood, A.
Ahmad, M.
Maheen, S.
Sher, M.
author_facet Sarfraz, R. M.
Khan, H. U.
Mahmood, A.
Ahmad, M.
Maheen, S.
Sher, M.
author_sort Sarfraz, R. M.
collection PubMed
description In this study, mouth-disintegrating tablets of atenolol and atorvastatin combination were formulated using superdisintegrants to impart fast disintegration. Fifteen formulations were prepared based on different concentrations of two superdisintegrants, croscarmellose sodium and Kyron-T(134). Three different techniques such as direct compression, effervescent and sublimation were used to study the effect of manufacturing processes, nature and concentration of superdisintegrants on various features of these tablets. Five formulations were made using each method. Precompression studies like bulk density, tapped density, angle of repose, Carr's compressibility index, Hausner's ratio and compatibility studies such as Fourier transform infrared spectroscopy and differential scanning calorimetry were performed. Various features such as hardness, thickness, diameter, weight variation, friability, disintegration time, dissolution studies, wetting time, wetting volume, water absorption ratio, modified disintegration, uniformity of contents and stability were evaluated. Finally results were statistically analyzed by the application of one way ANOVA test. Formulation F(13) containing Kyron-T(134) (6%) and croscarmellose sodium (2%) was found to be the best among all fifteen formulations prepared in all aspects evaluated. Sublimation method is found to be the best among three methods of preparation used.
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spelling pubmed-43558872015-03-12 Formulation and Evaluation of Mouth Disintegrating Tablets of Atenolol and Atorvastatin Sarfraz, R. M. Khan, H. U. Mahmood, A. Ahmad, M. Maheen, S. Sher, M. Indian J Pharm Sci Research Paper In this study, mouth-disintegrating tablets of atenolol and atorvastatin combination were formulated using superdisintegrants to impart fast disintegration. Fifteen formulations were prepared based on different concentrations of two superdisintegrants, croscarmellose sodium and Kyron-T(134). Three different techniques such as direct compression, effervescent and sublimation were used to study the effect of manufacturing processes, nature and concentration of superdisintegrants on various features of these tablets. Five formulations were made using each method. Precompression studies like bulk density, tapped density, angle of repose, Carr's compressibility index, Hausner's ratio and compatibility studies such as Fourier transform infrared spectroscopy and differential scanning calorimetry were performed. Various features such as hardness, thickness, diameter, weight variation, friability, disintegration time, dissolution studies, wetting time, wetting volume, water absorption ratio, modified disintegration, uniformity of contents and stability were evaluated. Finally results were statistically analyzed by the application of one way ANOVA test. Formulation F(13) containing Kyron-T(134) (6%) and croscarmellose sodium (2%) was found to be the best among all fifteen formulations prepared in all aspects evaluated. Sublimation method is found to be the best among three methods of preparation used. Medknow Publications & Media Pvt Ltd 2015 /pmc/articles/PMC4355887/ /pubmed/25767322 Text en Copyright: © Indian Journal of Pharmaceutical Sciences http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Paper
Sarfraz, R. M.
Khan, H. U.
Mahmood, A.
Ahmad, M.
Maheen, S.
Sher, M.
Formulation and Evaluation of Mouth Disintegrating Tablets of Atenolol and Atorvastatin
title Formulation and Evaluation of Mouth Disintegrating Tablets of Atenolol and Atorvastatin
title_full Formulation and Evaluation of Mouth Disintegrating Tablets of Atenolol and Atorvastatin
title_fullStr Formulation and Evaluation of Mouth Disintegrating Tablets of Atenolol and Atorvastatin
title_full_unstemmed Formulation and Evaluation of Mouth Disintegrating Tablets of Atenolol and Atorvastatin
title_short Formulation and Evaluation of Mouth Disintegrating Tablets of Atenolol and Atorvastatin
title_sort formulation and evaluation of mouth disintegrating tablets of atenolol and atorvastatin
topic Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4355887/
https://www.ncbi.nlm.nih.gov/pubmed/25767322
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