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The 763C>G Polymorphism of The Secretory PLA2IIa Gene Is Associated with Endometriosis in Iranian Women
BACKGROUND: Endometriosis is a chronic gynecological disease resulting from complex interactions between genetic, hormonal, environmental and oxidative stress and intrinsic inflammatory components. The aim of this study was to investigate the potential association of the 763C>G polymorphism in th...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Royan Institute
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4355930/ https://www.ncbi.nlm.nih.gov/pubmed/25780526 |
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author | Sahmani, Mehdi Darabi, Masoud Darabi, Maryam Dabaghi, Talaat Alizadeh, Safar Ali Najafipour, Reza |
author_facet | Sahmani, Mehdi Darabi, Masoud Darabi, Maryam Dabaghi, Talaat Alizadeh, Safar Ali Najafipour, Reza |
author_sort | Sahmani, Mehdi |
collection | PubMed |
description | BACKGROUND: Endometriosis is a chronic gynecological disease resulting from complex interactions between genetic, hormonal, environmental and oxidative stress and intrinsic inflammatory components. The aim of this study was to investigate the potential association of the 763C>G polymorphism in the secretory phospholipase A2 group IIa gene (PLA2G2A) with the risk of endometriosis in Iranian women. MATERIALS AND METHODS: Ninety seven patients with endometriosis along with 107 women who were negative for endometriosis after laparoscopy and laparatomy, and served as the control group, were enrolled for this cross-sectional study. Samples were genotyped using the polymerase chain reaction-restriction fragment length polymorphism method. RESULTS: Multivariate analysis was used to examine the association between the risk of endometriosis and the 763C>G polymorphism of PLA2G2A. Genotype distributions of PLA2G2A were significantly different between patients and the controls (p<0.001, OR=0.22, 95% CI=0.21-0.39). Correlation analysis showed that there was a significant association between the normal homozygous genotype and susceptibility to endometriosis (p<0.001). CONCLUSION: The present study suggests that the 763C>G polymorphism of PLA2G2A plays an important role as an independent factor in the risk of endometriosis in Iranian women. |
format | Online Article Text |
id | pubmed-4355930 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Royan Institute |
record_format | MEDLINE/PubMed |
spelling | pubmed-43559302015-03-16 The 763C>G Polymorphism of The Secretory PLA2IIa Gene Is Associated with Endometriosis in Iranian Women Sahmani, Mehdi Darabi, Masoud Darabi, Maryam Dabaghi, Talaat Alizadeh, Safar Ali Najafipour, Reza Int J Fertil Steril Original Article BACKGROUND: Endometriosis is a chronic gynecological disease resulting from complex interactions between genetic, hormonal, environmental and oxidative stress and intrinsic inflammatory components. The aim of this study was to investigate the potential association of the 763C>G polymorphism in the secretory phospholipase A2 group IIa gene (PLA2G2A) with the risk of endometriosis in Iranian women. MATERIALS AND METHODS: Ninety seven patients with endometriosis along with 107 women who were negative for endometriosis after laparoscopy and laparatomy, and served as the control group, were enrolled for this cross-sectional study. Samples were genotyped using the polymerase chain reaction-restriction fragment length polymorphism method. RESULTS: Multivariate analysis was used to examine the association between the risk of endometriosis and the 763C>G polymorphism of PLA2G2A. Genotype distributions of PLA2G2A were significantly different between patients and the controls (p<0.001, OR=0.22, 95% CI=0.21-0.39). Correlation analysis showed that there was a significant association between the normal homozygous genotype and susceptibility to endometriosis (p<0.001). CONCLUSION: The present study suggests that the 763C>G polymorphism of PLA2G2A plays an important role as an independent factor in the risk of endometriosis in Iranian women. Royan Institute 2015 2015-02-07 /pmc/articles/PMC4355930/ /pubmed/25780526 Text en Any use, distribution, reproduction or abstract of this publication in any medium, with the exception of commercial purposes, is permitted provided the original work is properly cited http://creativecommons.org/licenses/by/2.5/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Article Sahmani, Mehdi Darabi, Masoud Darabi, Maryam Dabaghi, Talaat Alizadeh, Safar Ali Najafipour, Reza The 763C>G Polymorphism of The Secretory PLA2IIa Gene Is Associated with Endometriosis in Iranian Women |
title | The 763C>G Polymorphism of The Secretory PLA2IIa
Gene Is Associated with Endometriosis
in Iranian Women |
title_full | The 763C>G Polymorphism of The Secretory PLA2IIa
Gene Is Associated with Endometriosis
in Iranian Women |
title_fullStr | The 763C>G Polymorphism of The Secretory PLA2IIa
Gene Is Associated with Endometriosis
in Iranian Women |
title_full_unstemmed | The 763C>G Polymorphism of The Secretory PLA2IIa
Gene Is Associated with Endometriosis
in Iranian Women |
title_short | The 763C>G Polymorphism of The Secretory PLA2IIa
Gene Is Associated with Endometriosis
in Iranian Women |
title_sort | 763c>g polymorphism of the secretory pla2iia
gene is associated with endometriosis
in iranian women |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4355930/ https://www.ncbi.nlm.nih.gov/pubmed/25780526 |
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