Replicative senescence is associated with nuclear reorganization and with DNA methylation at specific transcription factor binding sites

BACKGROUND: Primary cells enter replicative senescence after a limited number of cell divisions. This process needs to be considered in cell culture experiments, and it is particularly important for regenerative medicine. Replicative senescence is associated with reproducible changes in DNA methylat...

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Detalles Bibliográficos
Autores principales: Hänzelmann, Sonja, Beier, Fabian, Gusmao, Eduardo G, Koch, Carmen M, Hummel, Sebastian, Charapitsa, Iryna, Joussen, Sylvia, Benes, Vladimir, Brümmendorf, Tim H, Reid, George, Costa, Ivan G, Wagner, Wolfgang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4356053/
https://www.ncbi.nlm.nih.gov/pubmed/25763115
http://dx.doi.org/10.1186/s13148-015-0057-5

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