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Matrix metalloproteinase 9 (MMP-9) is indispensable for long term potentiation in the central and basal but not in the lateral nucleus of the amygdala

It has been shown that matrix metalloproteinase 9 (MMP-9) is required for synaptic plasticity, learning and memory. In particular, MMP-9 involvement in long-term potentiation (LTP, the model of synaptic plasticity) in the hippocampus and prefrontal cortex has previously been demonstrated. Recent dat...

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Autores principales: Gorkiewicz, Tomasz, Balcerzyk, Marcin, Kaczmarek, Leszek, Knapska, Ewelina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4356064/
https://www.ncbi.nlm.nih.gov/pubmed/25814930
http://dx.doi.org/10.3389/fncel.2015.00073
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author Gorkiewicz, Tomasz
Balcerzyk, Marcin
Kaczmarek, Leszek
Knapska, Ewelina
author_facet Gorkiewicz, Tomasz
Balcerzyk, Marcin
Kaczmarek, Leszek
Knapska, Ewelina
author_sort Gorkiewicz, Tomasz
collection PubMed
description It has been shown that matrix metalloproteinase 9 (MMP-9) is required for synaptic plasticity, learning and memory. In particular, MMP-9 involvement in long-term potentiation (LTP, the model of synaptic plasticity) in the hippocampus and prefrontal cortex has previously been demonstrated. Recent data suggest the role of MMP-9 in amygdala-dependent learning and memory. Nothing is known, however, about its physiological correlates in the specific pathways in the amygdala. In the present study we show that LTP in the basal and central but not lateral amygdala (LA) is affected by MMP-9 knock-out. The MMP-9 dependency of LTP was confirmed in brain slices treated with a specific MMP-9 inhibitor. The results suggest that MMP-9 plays different roles in synaptic plasticity in different nuclei of the amygdala.
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spelling pubmed-43560642015-03-26 Matrix metalloproteinase 9 (MMP-9) is indispensable for long term potentiation in the central and basal but not in the lateral nucleus of the amygdala Gorkiewicz, Tomasz Balcerzyk, Marcin Kaczmarek, Leszek Knapska, Ewelina Front Cell Neurosci Neuroscience It has been shown that matrix metalloproteinase 9 (MMP-9) is required for synaptic plasticity, learning and memory. In particular, MMP-9 involvement in long-term potentiation (LTP, the model of synaptic plasticity) in the hippocampus and prefrontal cortex has previously been demonstrated. Recent data suggest the role of MMP-9 in amygdala-dependent learning and memory. Nothing is known, however, about its physiological correlates in the specific pathways in the amygdala. In the present study we show that LTP in the basal and central but not lateral amygdala (LA) is affected by MMP-9 knock-out. The MMP-9 dependency of LTP was confirmed in brain slices treated with a specific MMP-9 inhibitor. The results suggest that MMP-9 plays different roles in synaptic plasticity in different nuclei of the amygdala. Frontiers Media S.A. 2015-03-11 /pmc/articles/PMC4356064/ /pubmed/25814930 http://dx.doi.org/10.3389/fncel.2015.00073 Text en Copyright © 2015 Gorkiewicz, Balcerzyk, Kaczmarek and Knapska. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution and reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neuroscience
Gorkiewicz, Tomasz
Balcerzyk, Marcin
Kaczmarek, Leszek
Knapska, Ewelina
Matrix metalloproteinase 9 (MMP-9) is indispensable for long term potentiation in the central and basal but not in the lateral nucleus of the amygdala
title Matrix metalloproteinase 9 (MMP-9) is indispensable for long term potentiation in the central and basal but not in the lateral nucleus of the amygdala
title_full Matrix metalloproteinase 9 (MMP-9) is indispensable for long term potentiation in the central and basal but not in the lateral nucleus of the amygdala
title_fullStr Matrix metalloproteinase 9 (MMP-9) is indispensable for long term potentiation in the central and basal but not in the lateral nucleus of the amygdala
title_full_unstemmed Matrix metalloproteinase 9 (MMP-9) is indispensable for long term potentiation in the central and basal but not in the lateral nucleus of the amygdala
title_short Matrix metalloproteinase 9 (MMP-9) is indispensable for long term potentiation in the central and basal but not in the lateral nucleus of the amygdala
title_sort matrix metalloproteinase 9 (mmp-9) is indispensable for long term potentiation in the central and basal but not in the lateral nucleus of the amygdala
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4356064/
https://www.ncbi.nlm.nih.gov/pubmed/25814930
http://dx.doi.org/10.3389/fncel.2015.00073
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