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Diagnosis and treatment of penile verrucous carcinoma
Penile verrucous carcinoma is an extremely rare disease that, at present, has not been well characterized. The etiology, diagnosis and treatment of this carcinoma remain poorly understood, particularly in the Chinese population. The aim of the present study was to discuss the methods of diagnosis an...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
D.A. Spandidos
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4356329/ https://www.ncbi.nlm.nih.gov/pubmed/25789024 http://dx.doi.org/10.3892/ol.2015.2909 |
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author | LI, FANGYIN XU, YIPENG WANG, HUA CHEN, BO WANG, ZONGPING ZHAO, YANG ZHU, SHAOXING CHEN, GUIPING |
author_facet | LI, FANGYIN XU, YIPENG WANG, HUA CHEN, BO WANG, ZONGPING ZHAO, YANG ZHU, SHAOXING CHEN, GUIPING |
author_sort | LI, FANGYIN |
collection | PubMed |
description | Penile verrucous carcinoma is an extremely rare disease that, at present, has not been well characterized. The etiology, diagnosis and treatment of this carcinoma remain poorly understood, particularly in the Chinese population. The aim of the present study was to discuss the methods of diagnosis and treatment of penile verrucous carcinoma in the Chinese population. The clinical and pathological data of 10 patients with penile verrucous carcinoma were analyzed alongside a literature review. All the tumors were exophytic papillary lesions, ranging between 0.4 and 4 cm in diameter and all 10 patients underwent partial penectomy with tumor-negative surgical margins. None of the 10 patients underwent ilioinguinal lymphadenectomy. All patients were regularly followed up for 0.7–9 years, which revealed that no patients developed recurrence, and only one case resulted in mortality due to unassociated causes. It was found that penile verrucous carcinoma is a well-differentiated disease with low malignant potential and locally aggressive features, which seldom metastasizes to regional lymph nodes or distant regions. However, misdiagnosis may occur due to an incorrect biopsy. Favorable outcomes can be achieved by surgery, even without any adjuvant therapy, but patients should be carefully followed up. |
format | Online Article Text |
id | pubmed-4356329 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | D.A. Spandidos |
record_format | MEDLINE/PubMed |
spelling | pubmed-43563292015-03-18 Diagnosis and treatment of penile verrucous carcinoma LI, FANGYIN XU, YIPENG WANG, HUA CHEN, BO WANG, ZONGPING ZHAO, YANG ZHU, SHAOXING CHEN, GUIPING Oncol Lett Articles Penile verrucous carcinoma is an extremely rare disease that, at present, has not been well characterized. The etiology, diagnosis and treatment of this carcinoma remain poorly understood, particularly in the Chinese population. The aim of the present study was to discuss the methods of diagnosis and treatment of penile verrucous carcinoma in the Chinese population. The clinical and pathological data of 10 patients with penile verrucous carcinoma were analyzed alongside a literature review. All the tumors were exophytic papillary lesions, ranging between 0.4 and 4 cm in diameter and all 10 patients underwent partial penectomy with tumor-negative surgical margins. None of the 10 patients underwent ilioinguinal lymphadenectomy. All patients were regularly followed up for 0.7–9 years, which revealed that no patients developed recurrence, and only one case resulted in mortality due to unassociated causes. It was found that penile verrucous carcinoma is a well-differentiated disease with low malignant potential and locally aggressive features, which seldom metastasizes to regional lymph nodes or distant regions. However, misdiagnosis may occur due to an incorrect biopsy. Favorable outcomes can be achieved by surgery, even without any adjuvant therapy, but patients should be carefully followed up. D.A. Spandidos 2015-04 2015-01-27 /pmc/articles/PMC4356329/ /pubmed/25789024 http://dx.doi.org/10.3892/ol.2015.2909 Text en Copyright © 2015, Spandidos Publications http://creativecommons.org/licenses/by/3.0 This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited. |
spellingShingle | Articles LI, FANGYIN XU, YIPENG WANG, HUA CHEN, BO WANG, ZONGPING ZHAO, YANG ZHU, SHAOXING CHEN, GUIPING Diagnosis and treatment of penile verrucous carcinoma |
title | Diagnosis and treatment of penile verrucous carcinoma |
title_full | Diagnosis and treatment of penile verrucous carcinoma |
title_fullStr | Diagnosis and treatment of penile verrucous carcinoma |
title_full_unstemmed | Diagnosis and treatment of penile verrucous carcinoma |
title_short | Diagnosis and treatment of penile verrucous carcinoma |
title_sort | diagnosis and treatment of penile verrucous carcinoma |
topic | Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4356329/ https://www.ncbi.nlm.nih.gov/pubmed/25789024 http://dx.doi.org/10.3892/ol.2015.2909 |
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