Proteasome inhibition and oxidative reactions disrupt cellular homeostasis during heme stress

Dual control of cellular heme levels by extracellular scavenger proteins and degradation by heme oxygenases is essential in diseases associated with increased heme release. During severe hemolysis or rhabdomyolysis, uncontrolled heme exposure can cause acute kidney injury and endothelial cell damage...

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Detalles Bibliográficos
Autores principales: Vallelian, F, Deuel, J W, Opitz, L, Schaer, C A, Puglia, M, Lönn, M, Engelsberger, W, Schauer, S, Karnaukhova, E, Spahn, D R, Stocker, R, Buehler, P W, Schaer, D J
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Original Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4356336/
https://www.ncbi.nlm.nih.gov/pubmed/25301065
http://dx.doi.org/10.1038/cdd.2014.154

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