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Three-dimensional structures of Plasmodium falciparum spermidine synthase with bound inhibitors suggest new strategies for drug design

The enzymes of the polyamine-biosynthesis pathway have been proposed to be promising drug targets in the treatment of malaria. Spermidine synthase (SpdS; putrescine aminopropyltransferase) catalyzes the transfer of the aminopropyl moiety from decarboxylated S-adenosylmethionine to putrescine, leadin...

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Detalles Bibliográficos
Autores principales:	Sprenger, Janina, Svensson, Bo, Hålander, Jenny, Carey, Jannette, Persson, Lo, Al-Karadaghi, Salam
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	International Union of Crystallography 2015
Materias:	Research Papers
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4356361/ https://www.ncbi.nlm.nih.gov/pubmed/25760598 http://dx.doi.org/10.1107/S1399004714027011

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