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Interaction of the amyloid precursor protein-like protein 1 (APLP1) E2 domain with heparan sulfate involves two distinct binding modes

Beyond the pathology of Alzheimer’s disease, the members of the amyloid precursor protein (APP) family are essential for neuronal development and cell homeostasis in mammals. APP and its paralogues APP-like protein 1 (APLP1) and APP-like protein 2 (APLP2) contain the highly conserved heparan sulfate...

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Detalles Bibliográficos
Autores principales:	Dahms, Sven O., Mayer, Magnus C., Roeser, Dirk, Multhaup, Gerd, Than, Manuel E.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	International Union of Crystallography 2015
Materias:	Research Papers
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4356362/ https://www.ncbi.nlm.nih.gov/pubmed/25760599 http://dx.doi.org/10.1107/S1399004714027114

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