Snapshots of ligand entry, malleable binding and induced helical movement in P-glycoprotein

P-glycoprotein (P-gp) is a transporter of great clinical and pharmacological significance. Several structural studies of P-gp and its homologs have provided insights into its transport cycle, but questions remain regarding how P-gp recognizes diverse substrates and how substrate binding is coupled t...

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Detalles Bibliográficos
Autores principales: Szewczyk, Paul, Tao, Houchao, McGrath, Aaron P., Villaluz, Mark, Rees, Steven D., Lee, Sung Chang, Doshi, Rupak, Urbatsch, Ina L., Zhang, Qinghai, Chang, Geoffrey
Formato: Online Artículo Texto
Lenguaje:English
Publicado: International Union of Crystallography 2015
Materias:
Research Papers
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4356375/
https://www.ncbi.nlm.nih.gov/pubmed/25760620
http://dx.doi.org/10.1107/S1399004715000978

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4356375/
https://www.ncbi.nlm.nih.gov/pubmed/25760620
http://dx.doi.org/10.1107/S1399004715000978

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