Cargando…
Snapshots of ligand entry, malleable binding and induced helical movement in P-glycoprotein
P-glycoprotein (P-gp) is a transporter of great clinical and pharmacological significance. Several structural studies of P-gp and its homologs have provided insights into its transport cycle, but questions remain regarding how P-gp recognizes diverse substrates and how substrate binding is coupled t...
Autores principales: | Szewczyk, Paul, Tao, Houchao, McGrath, Aaron P., Villaluz, Mark, Rees, Steven D., Lee, Sung Chang, Doshi, Rupak, Urbatsch, Ina L., Zhang, Qinghai, Chang, Geoffrey |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
International Union of Crystallography
2015
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4356375/ https://www.ncbi.nlm.nih.gov/pubmed/25760620 http://dx.doi.org/10.1107/S1399004715000978 |
Ejemplares similares
-
Functional characterization and discovery of modulators of SbMATE, the agronomically important aluminium tolerance transporter from Sorghum bicolor
por: Doshi, Rupak, et al.
Publicado: (2017) -
Lipid environment determines the drug-stimulated ATPase activity of P-glycoprotein
por: Tran, Nghi N. B., et al.
Publicado: (2023) -
The Malleability of Gold
Publicado: (1891) -
SnapShot: Enveloped Virus Entry
por: Mercer, Jason, et al.
Publicado: (2020) -
Migration of malleable penile prosthesis
por: Mohamed, Abdelrahman Yahya, et al.
Publicado: (2017)